当前位置： SCI文献检索 > PHYSIOLOGY & BEHAVIOR期刊下所有文献 > Effect of dietary supplementation with branched-chain amino acids on spontaneous motor activity and muscle function in beta,beta'-iminodipropionitrile-treated rats: a model for motorneuropathy.

Effect of dietary supplementation with branched-chain amino acids on spontaneous motor activity and muscle function in beta,beta'-iminodipropionitrile-treated rats: a model for motorneuropathy.

Abstract：

:Beta,beta'-iminodipropionitrile (IDPN)-induced muscle weakness in rats is a model for motorneuropathy diseases. The effects of oral administration of branched-chain amino acids on the progression of muscle weakness and muscle atrophy induced by the administration of IDPN in the drinking water, were investigated in this study. The spontaneous motor activity of the animals, as measured with a running wheel, slowly declined after IDPN administration, reaching a steady and low level at approximately week 15. Progressive muscle weakness and muscle atrophy were observed beginning at approximately 15 weeks after the initiation of administration of IDPN. Administration of branched-chain amino acids (BCAA) as a dietary supplement did not improve the lowered spontaneous motor activity seen in IDPN animals, but it did significantly improve measures of postural weakness and muscle strength [range of F values (2, 24) = 4.1-9.5, p < 0.05]. Plasma creatinine of the IDPN-treated rats was markedly elevated, and BCAA administration also significantly suppressed this elevation [F(2, 24) = 41.2, p < 0.05]. Moreover, although BCAA in plasma were elevated in the rats administered BCAA [range of F values (2, 21) = 25.7-29.7, p < 0.05], skeletal muscle showed no differences (at the p < 0.05 level) in the amounts of BCAA, whether or not BCAA were administered. These data suggest that the BCAA taken up in the skeletal muscle were utilized in the muscle of motorneuropathic rats and improved muscle function, such as energy metabolism, and that the BCAA treatment is one important therapeutic approach for retarding the progression of muscle weakness seen in certain neuromuscular disorders.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Kitahara Y,Maki T,Torii K

doi

10.1016/s0031-9384(97)00154-6

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

453-62

issue

3

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(97)00154-6

journal_volume

62

pub_type

杂志文章

相关文献

PHYSIOLOGY & BEHAVIOR文献大全
  • Homogeneity of thermal tasters and implications for mechanisms and classification.

    abstract：:Thermal tasting, an important type of individual variation in orosensation, is a phenomenon by which some individuals perceive thermally-induced taste sensations simply by having the tip of their tongue warmed or cooled. These individuals, known as thermal tasters, report a variety of thermally-elicited tastes (typica...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2020.113160

    authors： Thibodeau M,Bajec M,Saliba A,Pickering G

    更新日期：2020-12-01 00:00:00

  • Postweaning social experience and adult aggression in rats.

    abstract：:One group of male rats was reared continuously in small, stable colonies of three animals each during a ten-week period beginning when they were 46 days old. A second group of animals was also reared in small groups of three animals each but membership within these colonies was randomly changed at weekly intervals. Th...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(84)90373-1

    authors： Lore RK,Stipo-Flaherty A

    更新日期：1984-10-01 00:00:00

  • Neonatal catecholaminergic influence on behaviour and sexual hormones.

    abstract：:There is evidence of a sexually dimorphic effect of serotonin administration during the critical period of sexual differentiation on gonadal hormone secretion in adulthood. To investigate the possible involvement of catecholamines on these mechanisms, we have injected dopamine or noradrenaline intraventricularly into ...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(92)90175-2

    authors： González MI,Leret ML

    更新日期：1992-03-01 00:00:00

  • Chronic infusion of the amylin antagonist AC 187 increases feeding in Zucker fa/fa rats but not in lean controls.

    abstract：:Numerous studies have established the pancreatic B-cell hormone amylin as an important anorectic peptide affecting meal-ending satiety. In the present study, we investigated the effect of a chronic infusion of the amylin antagonist AC 187 on food intake. The studies were performed using obese Zucker fa/fa rats, which ...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2004.02.002

    authors： Grabler V,Lutz TA

    更新日期：2004-05-01 00:00:00

  • Learned contextual cue potentiates eating in rats.

    abstract：:Explicit cues associated with food consumption when hunger prevails will enhance eating when they are subsequently presented under conditions of satiety. Here we examined whether contextual conditioned stimuli (CSs) paired with consumption of food pellets while rats were food-deprived would enhance consumption of this...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2006.09.031

    authors： Petrovich GD,Ross CA,Gallagher M,Holland PC

    更新日期：2007-02-28 00:00:00

  • Competitive experience activates testosterone-dependent social aggression toward unfamiliar males.

    abstract：:Male hooded rats (350 to 450 g) were castrated and given subcutaneous implants of testosterone-filled or empty Silastic tubes. Four weeks later, half of the animals with testosterone implants were housed with an animal with an empty implant and left for 6 weeks. The other animals were adapted to a food-deprivation sch...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(89)90285-0

    authors： Albert DJ,Petrovic DM,Walsh ML

    更新日期：1989-04-01 00:00:00

  • Effects of bile duct ligation and captopril on salt appetite and renin-aldosterone axis in rats.

    abstract：:A ligation of the common bile duct (BDL) produces cholestasis and hypotension and increases the daily ingestion of sodium chloride solutions in rats. Low-dose captopril (CAP) treatment also modifies the ingestion of water and sodium in naive rats, and may do so in cholestatic rats. This study examined whether the elev...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/s0031-9384(98)00295-9

    authors： Lane JR,Starbuck EM,Johnson AK,Fitts DA

    更新日期：1999-05-01 00:00:00

  • The effect of photoperiod on development of sexual behavior and fertility in golden hamsters.

    abstract：:Male hamsters were raised on short (SD) or long (LD) photoperiods from birth, and the expression of sexual behavior at 6, 7, 10, and 14 weeks was compared. Neither mounting, intromissions, ejaculations, nor ultrasonic vocalizations differed in the two groups until 14 weeks of age, when these behaviors were performed m...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(87)90383-0

    authors： Cherry JA

    更新日期：1987-01-01 00:00:00

  • Transgenic mouse models of Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by a progressive loss of cognitive function. Despite considerable progress, a complete description of the molecular pathology of this disease has yet to be elucidated. In this respect, the need for an animal model that develops some or all aspects...

    journal_title：Physiology & behavior

    pub_type： 杂志文章,评审

    doi：10.1016/s0031-9384(01)00524-8

    authors： Janus C,Westaway D

    更新日期：2001-08-01 00:00:00

  • Lesion of descending 5-HT pathways increases zimeldine-induced waking in rats.

    abstract：:Sleep, waking, and EEG power spectra were investigated in rats with spinal 5,6-dihydroxytryptamine (5,6-DHT) lesions, following 20 mg/kg zimeldine or vehicle IP injections. 5,6-DHT selectively lesioned the descending serotonergic pathways. Lesion alone did not change sleep and waking stages compared to baseline, excep...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(94)00370-k

    authors： Bjørkum AA,Neckelmann D,Bjorvatn B,Ursin R

    更新日期：1995-05-01 00:00:00

  • The effect of caloric load and nutrient composition on induction of small intestinal satiety in dogs.

    abstract：:The influence of caloric load and nutrient composition on small intestinal satiety was investigated in six dogs with chronic esophageal fistulas. Dogs received small bowel infusion of a mixed nutrient liquid meal, a fat, carbohydrate, and a protein solution over two hours. Each infusion was given over a range of calor...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/s0031-9384(97)00107-8

    authors： Geoghegan JG,Cheng CA,Lawson C,Pappas TN

    更新日期：1997-07-01 00:00:00

  • The autonomic correlates of dysphoric rumination and post-rumination savoring.

    abstract：:Trait dysphoric rumination is a transdiagnostic factor associated with depression and anxiety that has also been linked with blunted respiratory sinus arrhythmia (RSA), an index of reduced emotion regulation capacity. However, the autonomic correlates of state dysphoric rumination remain unclear. We examined the physi...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2020.113027

    authors： Stone LB,Lewis GM,Bylsma LM

    更新日期：2020-10-01 00:00:00

  • Role of the area postrema in radiation-induced taste aversion learning and emesis in cats.

    abstract：:The role of the area postrema in radiation-induced emesis and taste aversion learning and the relationship between these behaviors were studied in cats. The potential involvement of neural factors which might be independent of the area postrema was minimized by using low levels of ionizing radiation (100 rads at a dos...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(86)90189-7

    authors： Rabin BM,Hunt WA,Chedester AL,Lee J

    更新日期：1986-01-01 00:00:00

  • Impaired prefrontal inhibition in schizophrenia: relevance for cognitive dysfunction.

    abstract：:In schizophrenia, critical deficits in cognitive functions appear to reflect altered neural processing in the prefrontal cortex (PFC). Given the essential role of inhibitory neurotransmission in mediating these cognitive functions, we sought to determine whether abnormalities in the inhibitory circuitry of the PFC may...

    journal_title：Physiology & behavior

    pub_type： 杂志文章,评审

    doi：10.1016/s0031-9384(02)00936-8

    authors： Volk DW,Lewis DA

    更新日期：2002-12-01 00:00:00

  • Concentration-detection functions for the odor of homologous n-acetate esters.

    abstract：:Using air-dilution olfactometry, we measured concentration-response functions for the odor detection of the homologous esters ethyl, butyl, hexyl, and octyl acetate. Stimuli were delivered by means of an 8-station vapor delivery device (VDD-8) specifically designed to capture odor detection performance by humans under...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2008.09.021

    authors： Cometto-Muñiz JE,Cain WS,Abraham MH,Gil-Lostes J

    更新日期：2008-12-15 00:00:00

  • Rapid post-oral stimulation of intake and flavor conditioning in rats by glucose but not a non-metabolizable glucose analog.

    abstract：:Mice adapted to drink a flavored saccharin solution (CS-) paired with intragastric (IG) self-infusions of water rapidly increase their intake of a new flavored solution (CS+) that is paired with IG glucose self-infusions. The present study extends this method to examine post-oral glucose appetition in rats. Food-restr...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2014.04.042

    authors： Ackroff K,Sclafani A

    更新日期：2014-06-22 00:00:00

  • Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial.

    abstract：:This work evaluated the effects of moderate physical exercise performed under hypoxic conditions on melatonin and sleep. Forty healthy men were randomized into four groups: Normoxia (N) (n = 10); Hypoxia (H) (n = 10); Exercise under Normoxia (EN) (n = 10); and Exercise under Hypoxia (EH) (n = 10). The observation peri...

    journal_title：Physiology & behavior

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.physbeh.2018.08.016

    authors： de Aquino Lemos V,Dos Santos RVT,Antunes HKM,Behn C,Viscor G,Lira FS,Bittar IGL,Caris AV,Tufik S,De Mello MT

    更新日期：2018-11-01 00:00:00

  • Conditioned taste aversion dependent regulation of amygdala gene expression.

    abstract：:The present experiments investigated gene expression in the amygdala following contingent taste/LiCl treatment that supports development of conditioned taste aversion (CTA). The use of whole genome chips and stringent data set filtering led to the identification of 168 genes regulated by CTA compared to non-contingent...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2011.11.001

    authors： Panguluri SK,Kuwabara N,Kang Y,Cooper N,Lundy RF

    更新日期：2012-02-28 00:00:00

  • Consolidation and expression of a shock-induced odor preference in rat pups is facilitated by opioids.

    abstract：:To support nipple attachment and huddling, rat pups must learn to approach and prefer maternal odor. Similar to other altricial species, rat pups have a sensitive period for learning this odor preference, which ends around postnatal day (PN) 10 and coincides with the emergence of walking. One characteristic of this se...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/s0031-9384(02)00961-7

    authors： Roth TL,Sullivan RM

    更新日期：2003-01-01 00:00:00

  • Thermal control of mother-young contact in Norway rats: factors mediating the chronic elevation of maternal temperature.

    abstract：:The chronically elevated heat production of lactating Norway rats makes them vulnerable to acute hyperthermia during pup contact and thereby limits the duration of such interactions. High lactational levels of progesterone and corticosterone may act in concert to increase maternal heat load. Specifically, progesterone...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(86)90094-6

    authors： Adels LE,Leon M

    更新日期：1986-01-01 00:00:00

  • Sex differences in stress responses: focus on ovarian hormones.

    abstract：:Women in the reproductive age are more vulnerable to develop affective disorders than men. This difference may attribute to anatomical differences, hormonal influences and environmental factors such as stress. However, the higher prevalence in women normalizes once menopause is established, suggesting that ovarian hor...

    journal_title：Physiology & behavior

    pub_type： 杂志文章,评审

    doi：10.1016/j.physbeh.2009.02.036

    authors： Ter Horst GJ,Wichmann R,Gerrits M,Westenbroek C,Lin Y

    更新日期：2009-05-25 00:00:00

  • Salicylate as a partial inhibitor of emotional fever and body weight set-point in rats: behavioral and neuroendocrine study.

    abstract：:In this article, we report findings from behavioral and neuroendocrine experiments in rats under pharmacologically induced antipyretic conditions. Endpoints included emotional fever, body weight setpoint, and in situ corticotropin-releasing hormone mRNA (CRHmRNA) expression. Nine male Wistar rats were treated with ace...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/s0031-9384(02)01002-8

    authors： Michel C,Frankham P,Cabanac M

    更新日期：2003-03-01 00:00:00

  • Effects of different timing of stress on corticosterone, BDNF and memory in male rats.

    abstract：:Learning and memory seem to be affected by chronic stress. Previous reports have considered chronic stress as a precipitating factor of different neuropsychological disorders, while others reported neurobiological adaptations following stress. The present study investigated the effects of chronic stress before, after,...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2014.12.004

    authors： Radahmadi M,Alaei H,Sharifi MR,Hosseini N

    更新日期：2015-02-01 00:00:00

  • Individual differences in temporal lobe sensory processing of threatening stimuli in the cat.

    abstract：:In Experiment I, neurosensory responses from three limbic areas in the cat brain were recorded when cats of differing defensive temperamental traits were exposed to species characteristic threat. The cats investigated were more or less defensive in response to rats and conspecific threat howls. The behavioral disposit...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(91)90264-o

    authors： Adamec RE

    更新日期：1991-03-01 00:00:00

  • Gender differences in smiling: An evolutionary neuroandrogenic theory.

    abstract：:Studies have found that, under a wide variety of social circumstances, females are more likely than males to smile. The present article offers a theoretical explanation for this difference based on the premise that testosterone (along with other sex hormones) has evolved the tendency to alter brain functioning in ways...

    journal_title：Physiology & behavior

    pub_type： 杂志文章,评审

    doi：10.1016/j.physbeh.2006.03.034

    authors： Ellis L

    更新日期：2006-07-30 00:00:00

  • Neuropeptide gamma: a mammalian tachykinin endowed with potent antidipsogenic action in rats.

    abstract：:Neuropeptide gamma (NP gamma) is a 21 aminoacid peptide belonging to the tachykinin (TK) family and including neurokinin A (NKA) in its C-terminal sequence. NP gamma possesses higher affinity than NKA for central NK-2 receptors; it shows lower affinity for NK-1 receptors, however, it potently stimulates salivary secre...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(95)00071-p

    authors： Polidori C,Staffinati G,Perfumi MC,de Caro G,Massi M

    更新日期：1995-09-01 00:00:00

  • Rhythm and blues: Influence of CLOCK T3111C on peripheral electrophysiological indicators of negative affective processing.

    abstract：:Dysfunction in the circadian system has been linked to emotion regulation and mood disorders with genetic variation in clock genes as likely contributors. Here, we focused on endophenotypes of affective processing and investigated in two independent samples of healthy individuals (n1=99, n2=108) whether genotypes of a...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2020.112831

    authors： Armbruster D,Brocke B,Kirschbaum C,Witt SH,Lesch KP,Strobel A

    更新日期：2020-05-15 00:00:00

  • Metabolic inter-organ relations by exercise of fed rat: carbohydrates, ketone body, and nitrogen compounds in splanchnic vessels.

    abstract：:Fed rats were exercised until exhaustion by almost 65% VO2max on a treadmill. In 2.5 min after the exercise, blood was collected from various vessels of the splanchnic bed. Metabolites, glucose, lactate, ketone body, and nitrogencompounds in the plasma, were measured. Glucose excretion from the liver was increased by ...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/0031-9384(94)00293-e

    authors： Hirai T,Minatogawa Y,Hassan AM,Kido R

    更新日期：1995-03-01 00:00:00

  • Examinations of the reward comparison hypothesis: The modulation of gender and footshock.

    abstract：:The reward comparison hypothesis suggests that drugs of abuse-induced conditioned saccharin suppression intake is due to the reward value of drugs of abuse that outweighs that of a saccharin solution dissociating from the aversive LiCl-induced conditioned taste aversion (CTA). Huang and Hsiao (2008) provided some conf...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2015.07.022

    authors： Huang AC,Wang CC,Wang S

    更新日期：2015-11-01 00:00:00

  • Androgen receptors in Purkinje neurons are modulated by systemic testosterone and sexual training in a region-specific manner in the male rat.

    abstract：:The androgen receptor (AR) is a widely distributed molecule indicating the spread actions of its ligand steroid, and plays an important role underlying male sexual behavior. Nevertheless, the influence of steroid hormones and their receptors on cerebellar neurons, as foundation of sexual behavior, is largely unknown. ...

    journal_title：Physiology & behavior

    pub_type： 杂志文章

    doi：10.1016/j.physbeh.2016.01.027

    authors： Perez-Pouchoulen M,Toledo R,Garcia LI,Perez-Estudillo CA,Coria-Avila GA,Hernandez ME,Carrillo P,Manzo J

    更新日期：2016-03-15 00:00:00