Abstract:
:The present experiments investigated gene expression in the amygdala following contingent taste/LiCl treatment that supports development of conditioned taste aversion (CTA). The use of whole genome chips and stringent data set filtering led to the identification of 168 genes regulated by CTA compared to non-contingent LiCl treatment that does not support CTA learning. Seventy-six of these genes were eligible for network analysis. Such analysis identified "behavior" as the top biological function, which was represented by 15 of the 76 genes. These genes included several neuropeptides, G protein-coupled receptors, ion channels, kinases, and phosphatases. Subsequent qRT-PCR analyses confirmed changes in mRNA expression for 5 of 7 selected genes. We were able to demonstrate directionally consistent changes in protein level for 3 of these genes; insulin 1, oxytocin, and major histocompatibility complex class I-C. Behavioral analyses demonstrated that blockade of central insulin receptors produced a weaker CTA that was less resistant to extinction. Together, these results support the notion that we have identified downstream genes in the amygdala that contribute to CTA learning.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Panguluri SK,Kuwabara N,Kang Y,Cooper N,Lundy RFdoi
10.1016/j.physbeh.2011.11.001subject
Has Abstractpub_date
2012-02-28 00:00:00pages
996-1006issue
4eissn
0031-9384issn
1873-507Xpii
S0031-9384(11)00519-1journal_volume
105pub_type
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