Abstract：
:Pain threshold was determined in female rats using the tail flick test. Latency to respond depended on the locus of the tail heated, with the most distal sites resulting in the shortest response times (Experiment 1). Tail flick latency also varied according to the time of day, with shorter response times recorded around the middle of the dark phase than near its beginning or after its end. This was the case for intact, for ovariectomized, and for ovariectomized, estradiol-treated rats (Experiment 2). However, response times also varied across the estrous cycle, with significantly shorter latencies recorded during estrus and metestrus. Ovariectomy abolished these fluctuations, and whereas administration of estradiol increased response times, progesterone had little effect (Experiment 3). These results suggest that site of tail heating, time of day, and presence of ovarian hormones can influence tail flick latency independently, thus demonstrating the complexity of the mechanisms that may contribute to pain threshold even within the same paradigm.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Martínez-Gómez M,Cruz Y,Salas M,Hudson R,Pacheco Pdoi
10.1016/0031-9384(94)90040-xsubject
Has Abstractpub_date
1994-04-01 00:00:00pages
651-7issue
4eissn
0031-9384issn
1873-507Xpii
0031-9384(94)90040-Xjournal_volume
55pub_type
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