Abstract:
:The influence of transient forebrain ischemia on behavioral performance, and the effect of intracerebroventricular (i.c.v.) injection of acidic fibroblast growth factor (aFGF) on such ischemia-induced deficits were examined in Mongolian gerbils by assessing learning and memory in two tasks: passive avoidance and Morris water maze. A 5-min period of forebrain ischemia led to learning and memory deficits in both tasks, and also to neuronal death in the hippocampal CA1 region. Continuous i.c.v. infusion of aFGF bilaterally into the lateral ventricules by osmotic minipumps over 2 days before, and 5 days after the ischemia (a total of 3.6 microg/gerbil) largely prevented both the ischemia-induced behavioral deficits and the neuronal death in the hippocampus. These observations suggest that the hippocampus is a critical site for the performance of the two tasks, and that aFGF has a protective effect against such ischemia-induced learning and memory deficits in gerbils.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Li AJ,Oomura Y,Sasaki K,Suzuki K,Hori Tdoi
10.1016/s0031-9384(98)00330-8subject
Has Abstractpub_date
1999-06-01 00:00:00pages
577-83issue
4eissn
0031-9384issn
1873-507Xpii
S0031-9384(98)00330-8journal_volume
66pub_type
杂志文章abstract::Isometric handgrip is commonly used in stress research because the task reliably increases sympathetic arousal. Various handgrip protocols have been used; they vary in handgrip strength, duration of grip, and the number of cycles of handgrip and rest. However, most protocols require the calibration of a maximum volunt...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.01.031
更新日期:2015-04-01 00:00:00
abstract::We examined the physiological and psychological status of men and women who spent the summer (n=100) and/or winter (n=85) seasons in Antarctica at McMurdo (latitude 78.48 S, elevation 12 m) and South Pole (latitude 90 S, elevation 3880 m) stations to determine whether there were any significant differences by severity...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.06.008
更新日期:2007-12-05 00:00:00
abstract::The EMG, ECG and the behavioral activity of seven rats were recorded for three days previous to and 24 hours after lesioning both caudate-putamen complexes. Following the lesion, the paradoxical sleep stage lengthened by about 248%, without noticeable changes in the slow wave sleep or in the waking stages. The greates...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(75)90133-x
更新日期:1975-01-01 00:00:00
abstract::The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweaning rats. Gastric preloads (5% b.wt) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn o...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00256-4
更新日期:1997-10-01 00:00:00
abstract::We have designed software for an Apple II GS microcomputer allowing simultaneous on-line monitoring of blood glucose level and neuronal firing frequency in experimental rats. Blood glucose level in the carotid blood was continuously measured by a glucose analyzer and digitized through an A/D board. The firing rate of ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(93)90285-n
更新日期:1993-05-01 00:00:00
abstract::The 24-hour sleep-wake cycle of untreated, normal rats and of capsaicin-treated rats was continuously recorded by telemetry. Recordings were made on two baseline days at 22 degrees C, two days at 29 degrees C, and two final days at 22 degrees C. In untreated animals the daily amount of waking was reduced by the elevat...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(83)90148-8
更新日期:1983-03-01 00:00:00
abstract::Mice are impaired relative to rats in place and matching-to-place learning when tests are given in a swimming pool. The rat advantage may stem from a superior spatial ability or from adaptation to a niche that has prepared them for competency in the water. In the present study, mice (C57BL/6) were compared with rats (...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(96)00176-x
更新日期:1996-11-01 00:00:00
abstract::Adult male Long-Evans rats (n = 9 per group) received daily exposure for 4 weeks to fluoxetine (0.75 mg FLUOX/kg body weight) or trimipramine (1.6 mg TRIMI/kg body weight). Separate tests of copulation, sexual motivation, and intermale aggressive behaviors were used to evaluate functional changes during chronic exposu...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)02088-8
更新日期:1996-03-01 00:00:00
abstract::Polychlorinated biphenyls are environmental contaminants known to affect neurobehavioral development in many laboratory studies using different animal models. Because of their bioaccumulation and long half-life they are a serious concern for our own species. The dioxin-like PCB congener 3,4,3',4'-tetrachlorobiphenyl (...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.10.022
更新日期:2005-01-31 00:00:00
abstract::Behavioral and physiological effects of alarm pheromones emanating from stressed conspecific animals were investigated. Experimentally naive male Wistar rats were exposed to the test chambers containing alarm pheromones, which had been released by other rats receiving foot shocks in the same chamber beforehand. Along ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(00)00370-x
更新日期:2001-01-01 00:00:00
abstract::The aim of this work was to study the evolution of rat food choice in relation to their age and metabolic parameters. Eighty Wistar rats were studied from birth to 13 weeks of age. At weaning, six litters were fed on a macronutrient self-selecting diet and four on a standard diet. In self-selecting males, protein inta...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(02)00676-5
更新日期:2002-05-01 00:00:00
abstract::Multiple unit activity (MUA) was recorded from the ventral tegmental area (VTA) and mesencephalic locomotor region (MLR) during copulatory behavior of freely moving male rats. Simultaneous accelerometric recordings of the copulatory pelvic thrusting performed by the male rat were taken to precisely correlate in time t...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(96)00367-8
更新日期:1997-02-01 00:00:00
abstract::Cranially mounted differential preamplifiers allowed visual unit activity, EEGs and sustained potential shifts to be monitored from the tectum of freely moving toads (Bufo bufo). Alert behavior was elicited by a moving visual stimulus. Movement of the stimulus in the receptive field of a unit elicited its activity and...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90264-6
更新日期:1984-03-01 00:00:00
abstract::Prior research has noted a relationship between an individual's height in adolescence and their personality development later in life. This study examined whether height in adolescence--net of possible confounding variables such as age and biological maturity--predicted polydrug use in adolescence and young adulthood....
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.09.013
更新日期:2012-01-18 00:00:00
abstract::Plasma corticosteroid circadian periodicity was determined in three groups of individual adult male rats. Categories were: post-subdiaphragmatic vagotomy, sham-operated, and controls. Blood was sampled every 4 hours over a 48-hour period with ad lib feeding and after a 13-day period on daytime (0930--1330) restriction...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90194-9
更新日期:1982-05-01 00:00:00
abstract::Rats obtained less food than normal on a cyclic-ratio schedule during brief, 1-hr exposure to either moderate hypobaric hypoxia (BP = 435 Torr, PO2 approximately equal to 91 Torr) or to hypoxic hypoxia (BP = 750 Torr, PO2, approximately equal to 90 Torr), but not during hypobaric exposure with 36.5% oxygen (BP = 435 T...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90266-9
更新日期:1982-09-01 00:00:00
abstract::Using a combination of injection cannula and recording electrode, the effect of 1 microliter of 3 mM verapamil upon the multiunit responses evoked in the peripeduncular nucleus (PPN) by electric stimuli applied to the pudendal nerves in urethane anesthetized proestrous female rats was studied in 9 experiments. It was ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(88)90170-9
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:Axonal transport deficit is a key mechanism involved in neurodegenerative conditions. Fluoxetine, a commonly used antidepressant for treatment of depression, is known to regulate several important structural and neurochemical aspects of hippocampal functions. However, the mechanisms underlying these effect...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113140
更新日期:2020-12-01 00:00:00
abstract::The amphibian tetradecapeptide bombesin (BN) decreases food intake in both humans and animals. Studies have typically examined the effects of BN on scheduled meals in deprived subjects. To investigate the properties of this peptide under more naturalistic conditions, we examined the effects of BN in spontaneously feed...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)02136-1
更新日期:1996-02-01 00:00:00
abstract::Binge eating disorder (BED), characterized by excessive food consumption within a discrete period of time, is the most prevalent of all eating disorders, with higher rates in women than men. Chronic stress, particularly during adolescence, is a significant risk factor for BED in women, but the mechanism underlying thi...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113194
更新日期:2021-01-01 00:00:00
abstract::We have previously established the rewarding value of clitoral stimulation (CLS) through the demonstration that manual, distributed, CLS induces a significant conditioned place preference (CPP) and conditioned partner preference in naïve, hormonally primed and non-hormonally primed rats. The present experiment asks wh...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2013.06.005
更新日期:2013-07-02 00:00:00
abstract::We have previously shown that smell has no effect on resting parotid salivary flow in humans. In this study we investigated the effect of two odours on unilateral parotid salivary flow stimulated by either mastication or mastication with gustation. Neither odour stimulated flow above that elicited by either masticatio...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90470-m
更新日期:1992-12-01 00:00:00
abstract::Tonic immobility (TI) is considered to be a final stage in a sequence of defensive responses occurring in the prey/predator encounter. It is known that the basal midbrain of toads is involved in the organization of defensive behavior and analgesia. This study investigated the effect of electrolytic or neurotoxic lesio...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(00)00433-9
更新日期:2001-02-01 00:00:00
abstract::The circadian rhythm of hamster locomotor activity "splits" into two distinct circadian components during conditions of constant illumination. To determine if the circadian rhythm of body temperature also splits under these conditions, body temperature and locomotor activity were monitored concurrently in animals hous...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90191-4
更新日期:1984-05-01 00:00:00
abstract::Prior work indicates that rats prefer a mixture of sucrose and maltodextrin to either carbohydrate alone. The present experiment examined whether a sucrose + maltodextrin (S + M) mixture also increases total fluid intake as does saccharin + carbohydrate mixtures. In 23 h/day, one-bottle tests male rats consumed more o...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00478-2
更新日期:1998-02-15 00:00:00
abstract::Vocal communication is common among social vertebrates, though little is known about the neural mechanisms regulating the motivation to communicate. This study examined a possible role for dopamine and opioids in sexually motivated song in male European starlings. The dopamine reuptake inhibitor GBR-12909 increased si...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.05.011
更新日期:2006-07-30 00:00:00
abstract:BACKGROUND:Hydrogen sulfide (H2S) is the third gasotransmitter recently discovered after nitric oxide (NO) and carbon monoxide. Both NO and H2S are involved in multiple physiological functions. Whereas NO has been shown to vary with psychological stress, the influence of stress on H2S and the relationship between H2S a...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2017.05.023
更新日期:2017-10-01 00:00:00
abstract::To test the hypothesis that hepatic vagal afferents mediate the satiety effect of pancreatic glucagon, we tested the effects of selective surgical and pharmacological lesions of the abdominal vagus on glucagon's potency to inhibit feeding. Surgical disconnection of only the hepatic branch of the abdominal vagus blocke...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(83)90207-x
更新日期:1983-09-01 00:00:00
abstract::The aim of the present study was to investigate the modulatory action of different concentrations of circulating corticosterone occupying either predominantly mineralocorticoid receptors (MR) or both MR and glucocorticoid receptors (GR) in control of cardiovascular responses to a novelty stressor. Six groups of rats w...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(01)00642-4
更新日期:2002-02-01 00:00:00
abstract::The non-absorbable substitute for dietary triacylglycerol, olestra, has been marketed in the United States for fifteen years. Olestra is comprised of sucrose with six to eight of its hydroxyl groups forming ester links with long-chain fatty acids. Because olestra is not hydrolyzed by fat-splitting enzymes in the small...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2011.12.018
更新日期:2012-03-20 00:00:00