Preloads of corn oil inhibit independent ingestion on postnatal day 15 in rats.

Abstract:

:The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweaning rats. Gastric preloads (5% b.wt) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn oil decreased intake significantly compared with preloads of mineral oil or water on Postnatal Days 15 and 18, but not on Postnatal Day 12. Because preloads of corn oil reduced intake ore than preloads of mineral oil, it is possible that the inhibitory effect of corn oil is due to its fats rather than to its oily texture. Cholecystokinin (CCK), presumably released from the small intestine, apparently mediates part of this inhibitory effect because pretreatment with devazepide, a specific CKKA antagonist, significantly reduced the inhibition produced by corn oil.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Weller A,Gispan IH,Armony-Sivan R,Ritter RC,Smith GP

doi

10.1016/s0031-9384(97)00256-4

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

871-4

issue

4

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(97)00256-4

journal_volume

62

pub_type

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