Abstract：
:The obesity epidemic is a major health and economic burden facing both developed and developing countries worldwide. Interrogation of the central and peripheral mechanisms regulating ingestive behaviors have primarily focused on food intake, and in the process uncovered a detailed neuroanatomical framework controlling this behavior. However, these studies have largely ignored the behaviors that bring animals, including humans, in contact with food. It is therefore useful to dichotomize ingestive behaviors as appetitive (motivation to find and store food) and consummatory (consumption of food once found), and utilize an animal model that naturally displays these behaviors. Recent advances in genetics have facilitated the identification of several neuronal populations critical for regulating ingestive behaviors in mice, and novel functions of these neurons and neuropeptides in regulating appetitive behaviors in Siberian hamsters, a natural model of food foraging and food hoarding, have been identified. To this end, hypothalamic agouti-related protein/neuropeptide Y expressing neurons (AgRP neurons) have emerged as a critical regulator of ingestive behaviors. Recent studies by Dr. Timothy Bartness and others have identified several discrete mechanisms through which peripheral endocrine signals regulate AgRP neurons to control food foraging, food hoarding, and food intake. We review here recent advances in our understanding of the neuroendocrine control of ingestive behaviors in Siberian hamsters and other laboratory rodents, and identify novel mechanisms through which AgRP neurons mediate appetitive and consummatory behaviors.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Thomas MA,Xue Bdoi
10.1016/j.physbeh.2017.10.006subject
Has Abstractpub_date
2018-06-01 00:00:00pages
34-42eissn
0031-9384issn
1873-507Xpii
S0031-9384(17)30344-Xjournal_volume
190pub_type
杂志文章,评审abstract：:Previous studies have shown that adult male rats, in which brain estrogen formation was inhibited neonatally by SC administration of the aromatase inhibitor 1,4, 6-androstatriene-3,17-dione (ATD), show an altered sexual partner preference. When tested in a three-compartment box, such gonadally intact ATD males approac...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(96)80023-0
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0031-9384(92)90293-b
更新日期：1992-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.12.014
更新日期：2006-08-30 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90369-5
更新日期：1985-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,meta分析
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更新日期：2012-06-06 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/0031-9384(91)90198-w
更新日期：1991-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90198-4
更新日期：1989-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1998-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1990-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1984-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1984-04-01 00:00:00
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更新日期：1994-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1997-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2011-10-24 00:00:00
abstract：:Studies from this and other laboratories have demonstrated that sympathetic-adrenal medullary responses are reduced in laboratory rats exposed to chronic intermittent stress. To extend these findings, we have conducted three experiments in which laboratory rats were exposed daily for 26 consecutive days to the same (h...
journal_title：Physiology & behavior
pub_type： 杂志文章
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