Abstract：
:Zebrafish (Danio rerio) are rapidly becoming a popular animal model for neurobehavioral and psychopharmacological research. While startle testing is a well-established assay to investigate anxiety-like behaviors in different species, screening of the startle response and its habituation in zebrafish is a new direction of translational biomedical research. This study focuses on a novel behavioral protocol to assess a tapping-induced startle response and its habituation in adult zebrafish that have been pharmacologically-induced to exhibit anxiety/depression-like behaviors. We demonstrated that zebrafish exhibit robust learning performance in a task adapted from the mammalian literature, a modified plus maze, and showed that ethanol and fluoxetine impair memory performance in this maze when administered after training at a dose that does not impair motor function, however, leads to significant upregulation of hippocampal serotoninergic neurons. These results suggest that the maze associative learning paradigm has face and construct validity and that zebrafish may become a translationally relevant study species for the analysis of the mechanisms of learning and memory changes associated with psychopharmacological treatment of anxiety/depression.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Pittman JT,Lott CSdoi
10.1016/j.physbeh.2013.10.023subject
Has Abstractpub_date
2014-01-17 00:00:00pages
174-9eissn
0031-9384issn
1873-507Xpii
S0031-9384(13)00351-Xjournal_volume
123pub_type
杂志文章abstract：:Predation of manila clams (Ruditapes philippinarum) by swimming crabs (Portunus trituberculatus) and Japanese stone crabs (Charybdis japonica) was compared in the laboratory under different starvation regimes by a video recording analysis system, and the mechanism of foraging behavior differences between them combined...
journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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doi：10.1016/j.physbeh.2003.09.004
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journal_title：Physiology & behavior
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doi：10.1016/0031-9384(89)90124-8
更新日期：1989-02-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2015-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90025-9
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90098-7
更新日期：1983-07-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1992-11-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1995-12-01 00:00:00
abstract：:Parasagittal knife cuts through the perifornical hypothalamus either medial or lateral to the fornix produced hyperphagia and obesity and altered the rat's ingestive responses to dilute glucose solutions. The lateral knife cut rats drank less dilute glucose solution under both nondeprived and food deprived conditions ...
journal_title：Physiology & behavior
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更新日期：1975-07-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1983-03-01 00:00:00
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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更新日期：2013-02-17 00:00:00
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