The sites of action of cholecystokinin in decreasing meal size in pigs.

Abstract:

:The synthetic octapeptide of cholecystokinin (CCK-8) was infused at the rate of 67 ng/kg-minute into the jugular vein, carotid artery, portal vein, gastric branch of the splenic artery, and aortic artery both craniad and caudad to the origins of the cranial mesenteric and coeliac arteries of 39 young female pigs. Jugular, carotid and cranial erotic infusions resulted in significant reduction of meal size respectively to 65, 67 and 71% of control meal size (p less than 0.05). Gastric artery infusion resulted in a significant increase of meal size to 122% of control meal size (p less than 0.05). Portal vein and caudal aortic artery infusions had no significant effects on meal size. The results were interpreted as indicating a major site of action of CCK in reducing meal size in the bed of the cranial mesenteric or coeliac arteries, but excluding the stomach and liver.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Houpt TR

doi

10.1016/s0031-9384(83)80005-5

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

693-8

issue

5

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(83)80005-5

journal_volume

31

pub_type

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