Long-term recordings from afferent taste fibers.

Abstract:

:The receptor cells of taste buds have a life span of about 10 days but it is not known if response characteristics of these receptors alter during the turnover cycle. To examine taste cell responses over time, a micromachined polyimide sieve electrode array was implanted between the cut ends of the rat chorda tympani nerve, which then regenerated through the electrode array. Long-term stable recordings from regenerated single afferent fibers innervating taste buds were possible using this technique for up to 21 days. Responses to taste stimuli recorded from the same fiber changed with time. The changes occurred in both the magnitude of response and the relative response profiles to four chemical stimuli, NaCl, sucrose, HCl, and quinine HCl. These changes in response characteristics were hypothesized to result from changes in the taste receptor cells as the receptor cells turnover in the taste buds.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Shimatani Y,Nikles SA,Najafi K,Bradley RM

doi

10.1016/j.physbeh.2003.08.009

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

309-15

issue

2-3

eissn

0031-9384

issn

1873-507X

pii

S0031938403002725

journal_volume

80

pub_type

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