Modulation of male mouse sociosexual and anxiety-like behaviors by vasopressin receptors.

Abstract:

:Although the involvement of two types of vasopressin (AVP) receptors, v1a and v1b, in neural regulation of social behavior is well documented in rodents, there is no report on combined actions of them in regulation of social behavior. In this study, we investigated behavioral differences between wild-type (WT) and v1a and v1b double knockout (dKO) mice. For this, we measured olfactory preference, sexual behavior with receptive females (four weekly tests) in an enriched large observation cage, and anxiety-like behaviors. No difference between WT and dKO mice was found in olfactory preferences for estrous female odor to male odor. Over all four mating tests, the number of mounts and pursuits after receptive females was significantly greater in dKO mice than in WT mice. In the elevated plus maze and the open field test, dKO mice showed lower anxiety-like behavior than WT mice. Finally, we measured approach behavior to several types of objects, figurines, and caged anestrous or estrous females placed in the open field apparatus. The only difference observed was that dKO mice spent longer in the vicinity of estrous females than did WT mice. These findings suggest that vasopressin receptors are involved in the regulation of sociosexual behavior, presumably partly mediated by emotional responses, in male mice.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Shimizu K,Nakamura K,Yokosuka M,Kondo Y

doi

10.1016/j.physbeh.2018.09.016

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

37-41

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(18)30283-X

journal_volume

197

pub_type

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