Abstract:
:The neuropeptide galanin is widely distributed throughout the central nervous system with multiple and diverse biological functions mediated by different receptor subtypes. In the rat, galanin-like immunoreactivity is expressed in a population of 5-hydroxytryptamine (5-HT, serotonin) neurons in the dorsal raphe with extensive projections to the forebrain areas, e.g., hippocampus. This review summarizes results from experimental studies in rodents showing that in vivo galanin is a potent modulator of brain 5-HT transmission, and in particular 5-HT1A receptor-mediated functions. Galanin, given intracerebroventricular (i.c.v.), was demonstrated to have strong inhibitory interactions with 5-HT1A receptor functions, particularly in the dorsal raphe but also in the hippocampus. Since pre- and postsynaptic 5-HT1A receptors in the dorsal raphe and hippocampus are implicated in the action of antidepressant drugs and in depressive disorders, it is suggested that galanin receptors may be an important target for development of novel antidepressant drugs. This view is supported by a recent study in the rat showing that the galanin antagonist M35, given i.c.v., could block the depression-like behavior in the forced swim test induced by galanin, while M35 produced an antidepressant-like effect on its own.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Ogren SO,Razani H,Elvander-Tottie E,Kehr Jdoi
10.1016/j.physbeh.2007.05.022subject
Has Abstractpub_date
2007-09-10 00:00:00pages
172-9issue
1-2eissn
0031-9384issn
1873-507Xpii
S0031-9384(07)00208-9journal_volume
92pub_type
杂志文章,评审abstract::The behavior of primiparous lactating prairie voles (Microtus ochrogaster) and their mates individually interacting with pups was continuously assessed for 45 min after a 2-h parent-litter separation on days 3-4 and 10-11 postpartum. Both sexes were highly parental after reunion with the young, and their general patte...
journal_title:Physiology & behavior
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1999-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:2004-10-15 00:00:00
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journal_title:Physiology & behavior
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更新日期:2017-02-01 00:00:00
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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更新日期:2002-02-01 00:00:00
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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