Abstract：
:Previous work in our laboratory has found that whereas medial septal lesions impaired an operant left-right delayed alternation task in rats, the lesion also facilitated the performance of rats on a cued go/no-go discrimination task with a delay between the cue and the required response. These findings suggested to us that the medial septal lesions impaired "response" working memory, which in turn led to a compensatory enhancement of attention to stimulus cues. If this hypothesis is true, then the lesions should impair a go/no-go task based on "response" working memory. The current experiment tested this hypothesis. Rats (12 with medial septal lesions and 12 with sham operations) were tested on a discrete trial operant go/no-go response alternation task. The rats were first tested for 20 days without a delay contingency, followed by 35 days of testing with a 15-s delay between "go" and "no-go" trials. Both groups became proficient at the task under nondelay conditions and their terminal performance (averaging about 85% correct) did not differ. However, under delay conditions the performance of the lesioned rats was significantly impaired compared to the controls. As the go/no-go task does not require a spatial discrimination, the best explanation for our findings is that the lesions impaired response working memory.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Numan R,Feloney MP,Pham KH,Tieber LMdoi
10.1016/0031-9384(95)02044-6subject
Has Abstractpub_date
1995-12-01 00:00:00pages
1263-71issue
6eissn
0031-9384issn
1873-507Xpii
0031938495020446journal_volume
58pub_type
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更新日期：1985-01-01 00:00:00
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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doi：10.1016/s0031-9384(99)00059-1
更新日期：1999-08-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1982-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90090-b
更新日期：1991-08-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2015-11-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1993-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1994-08-01 00:00:00
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更新日期：2013-07-02 00:00:00
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更新日期：1998-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1983-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1982-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.02.002
更新日期：2004-05-01 00:00:00
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journal_title：Physiology & behavior
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doi：10.1016/j.physbeh.2005.08.037
更新日期：2006-01-30 00:00:00
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
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更新日期：2009-08-04 00:00:00
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更新日期：1991-03-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1991-06-01 00:00:00
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更新日期：1996-09-01 00:00:00
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更新日期：1992-09-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2004-08-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2000-09-15 00:00:00
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journal_title：Physiology & behavior
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更新日期：2008-10-20 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.01.002
更新日期：2011-03-28 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90307-n
更新日期：1992-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90275-2
更新日期：1988-01-01 00:00:00
