Peripheral administration of bombesin increases metabolism in the rat.

Abstract:

:Bombesin has been shown to decrease food intake and increase the duration of slow wave sleep, as well as to increase blood glucose and glucagon. A suspected mechanism of bombesin's anorexigenic and hypnogenic action could be via its possible effect on the enhancement of metabolism itself. Therefore, the effect of bombesin on rat metabolism was investigated in an open circuit computerized respirometer. This device was specifically conceived to extract the fraction of metabolism which is not due to the energy cost of muscular effort. This fraction of metabolism was designed background metabolism. In the absence of food, peripheral administration of bombesin increased the background metabolism at all doses. The higher dose of bombesin (32 micrograms/kg IP) elicited a four-hour enhancement of background metabolism, the magnitude of which was equivalent to that induced by a meal of about 1.5 grams. Therefore, it is suggested that the effect of bombesin on feeding and sleep could be achieved, at least partly, by its effect on the background metabolism, which ultimately may modulate the behavioral responses.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Even PC,de Saint Hilaire Z,Nicolaïdis S

doi

10.1016/0031-9384(91)90262-m

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

439-42

issue

3

eissn

0031-9384

issn

1873-507X

pii

0031-9384(91)90262-M

journal_volume

49

pub_type

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