Abstract：
:The objective of this study was to examine the effect of chronic dietary restriction on the physical characteristics of the intestine and gut-derived satiety hormone production. Male Wistar rats (8 weeks) were randomized to ad libitum (AL) or 35% dietary restriction (DR) for 5 months. At the end of the study, physical measurements were made on the intestine and satiety hormone secretion and mRNA expression determined. A comparison group of young, growing AL rats (5 weeks) was also examined. The adult DR rats gained less weight over 5 months and had lower fat mass than adult AL rats (p<0.05). The weight of the small intestine as a percentage of total body weight was greater in adult DR compared to adult AL but lower than young AL rats. Compared to AL, DR down-regulated proglucagon and cholecystokinin mRNA in the duodenum and ghrelin mRNA in the stomach of adult rats but was not different from young AL. Ghrelin-O-acyltransferase (GOAT) mRNA in the stomach was up-regulated 21-fold in adult AL rats compared to young AL and 14-fold compared to adult DR rats. Total and des-acyl ghrelin was approximately 50% higher in adult DR and young AL rats compared to adult AL. Plasma leptin and insulin were lower in adult DR and young AL rats compared to adult AL. Our findings suggest that long-term energy deficits continue to drive up ghrelin levels which may have profound implications for practical implementation of DR as an anti-aging or anti-obesity strategy in humans.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Reimer RA,Maurer AD,Lau DC,Auer RNdoi
10.1016/j.physbeh.2010.01.034subject
Has Abstractpub_date
2010-04-19 00:00:00pages
605-10issue
5eissn
0031-9384issn
1873-507Xpii
S0031-9384(10)00047-8journal_volume
99pub_type
杂志文章abstract：:Female rats which had been ovariectomized either 7 days earlier (short-term deprivation, N = 11) or 35 days earlier (long-term deprivation, N = 11) were tested for their response to treatments of estradiol benzoate (6.0 micrograms/kg body weight) and progesterone (1.2 mg/kg). The long-term deprived females showed less...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90253-7
更新日期：1985-12-01 00:00:00
abstract：:Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine. These rats displayed enhanced intragroup aggression but normal muricide; gustatory neophobia and conditioned taste aversion were virtually el...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90261-d
更新日期：1993-05-01 00:00:00
abstract：:Epidemiological evidence indicates that physical activity between menarche and first pregnancy is associated with a lower risk of breast cancer among women with at least 20years between these reproductive events. The mechanism by which physical activity during this interval confers protection is unknown. This study us...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.11.026
更新日期：2017-02-01 00:00:00
abstract：:Chronic nutritional stress can have a negative impact on an individual's learning ability and memory. However, in social animals that share food among group members, such as the honey bee (Apis mellifera L.), it is unknown whether group-level nutritional stress is manifested in the learning performance of individuals....
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.08.003
更新日期：2008-12-15 00:00:00
abstract：:Changes were studied in the open-field behavior of young rats prematurely separated from their mothers at different ages. Premature separation from the mother on days 15 and 18 of life increased their fear or emotional behavior, as measured by the amount of defecation and locomotor activity. The changes in rats' open-...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90272-1
更新日期：1987-01-01 00:00:00
abstract：:Gold thioglucose (GTG) has been known to be an obesity causing agent for over 40 years. GTG works by affecting dendrites in the mouse ventromedial hypothalamus (VMH) producing a permanent VMH lesion and subsequent hyperphagia and obesity. We have investigated the effect of beta-thioglucose (BTG), a glucose antimetabol...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90005-x
更新日期：1989-09-01 00:00:00
abstract：BACKGROUND:Voiding disorders in humans, particularly in children are associated with increased incidence of behavioral issues as well as past history of childhood abuse. We hypothesized that creating stress in mice, utilizing either a chronic social defeat model (SD) or restraint stress in shallow water model (RSSW) wo...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.02.021
更新日期：2015-10-15 00:00:00
abstract：BACKGROUND:Otitis media (OM), or middle ear infections, are one of the most common diseases during early childhood. OM has been linked to changes in food preferences through potential effects on taste signalling, and thereby, to increased weight. OBJECTIVES:We investigated the associations between OM, taste sensitivit...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112570
更新日期：2019-09-01 00:00:00
abstract：:Although the involvement of two types of vasopressin (AVP) receptors, v1a and v1b, in neural regulation of social behavior is well documented in rodents, there is no report on combined actions of them in regulation of social behavior. In this study, we investigated behavioral differences between wild-type (WT) and v1a...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.09.016
更新日期：2018-12-01 00:00:00
abstract：:Associative conditioning of satiety indicates that concentrated maltodextrin (cMD) may induce a mildly aversive visceral signal within 20 min of its ingestion, as well as satiating normally. Individuals' awareness of this adverse state was tested on ratings of statistically distinct descriptions of factors liable to s...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.11.027
更新日期：2011-03-01 00:00:00
abstract：:Nicotine exposure during development can alter behavior in adulthood in mice. One route of nicotine administration that can mimic some of the dynamics of human smoking is administration of the drug to pregnant and nursing mice through the drinking water. It is critical to determine if nicotine administration has an im...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.08.021
更新日期：2010-12-02 00:00:00
abstract：:Withdrawal from progesterone and estradiol has been used as an animal model of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). In the clinical population individual sensitivity to sex steroid hormones, personality and heredity influence PMS/PMDD. Understanding the phenotypic risk factors of PMS...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.08.015
更新日期：2009-01-08 00:00:00
abstract：:The present study aimed to evaluate the effects of a highly-demanding match and a lowly-demanding match on pre-competitive heart rate variability (HRV) and anxiety in semi-professional female soccer athletes. A total of 14 players, with a mean age of 23.78 (4.93), from the Cáceres Women Football Club of the Spanish Se...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.112926
更新日期：2020-08-01 00:00:00
abstract：:In three experiments, startle responses to brief intense tone-bursts (30 msec, 110 dB, 6000 Hz) and single pulse (0.1 msec) stimulation of the cochlear nucleus and the nucleus reticularis pontis caudalis are studied under high pressures of heliox (from 0 bar to 50 bars) in the rat. For each rat (N = 12), mean amplitud...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90076-5
更新日期：1988-01-01 00:00:00
abstract：:The subfornical organ (SFO), as one of the sensory circumventricular organs (CVOs), is among the only central nervous system structures which interfaces directly with circulating substances that do not cross the blood brain barrier. Here we describe a growing literature showing that circulating indicators of cardiovas...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2013.02.012
更新日期：2013-09-10 00:00:00
abstract：:Anterior perifornical hypothalamic injection of l-norepinephrine in satiated rats elicits a brief, vigorous drinking response followed within a minute or two by a vigorous feeding response. These adrenergically elicited responses, which bear striking similarities to a rat's naturally motivated ingestive behaviors, wer...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(75)90066-9
更新日期：1975-06-01 00:00:00
abstract：:Housing mice in the presence of small particles of titanium has been shown to reduce stress-responsive behavior via the autonomic nervous system. Here, we examined the effects of nighttime titanium exposure on stress parameters and autonomic nerve activity in office workers with emotional stress. A randomized double-b...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2012.09.009
更新日期：2012-12-25 00:00:00
abstract：BACKGROUND:This cohort study evaluates whether the association between low-grade inflammation and incident depressive symptoms is independent of abdominal obesity and metabolic disturbances. METHODS:A cohort of 1167 non-depressed men aged 35 to 80 years were followed up over 5 years to assess incident depressive sympt...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.11.058
更新日期：2015-02-01 00:00:00
abstract：:Evaluation of the participation of different substantia nigra sites in the sensitization of resistant (R) animals to audiogenic seizures (AS), was performed after series of small (5 mC; n = 28), medium (10 mC; n = 57) and large (15 mC; 3 points of 5 mC each, n = 19) unilateral electrolytic lesions of the substantia ni...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00050-s
更新日期：1995-08-01 00:00:00
abstract：:Major histocompatibility complex (MHC) genes influence urinary odors (odortypes) of mice. That volatile odorants are involved is supported by the observation that odortype identity can be detected from a distance. Furthermore, chemical analyses of urines have revealed numerous volatile odorants that differ in relative...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.10.003
更新日期：2009-01-08 00:00:00
abstract：:We describe and test a programmable feeding system based on a contact eatometer, previously developed in our laboratory, consisting of a swinging grid beneath a hopper that is moved by the rat each time it wants to eat. This has not been connected to a solenoid that can block the movement of the grid to prevent access...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02225-2
更新日期：1996-06-01 00:00:00
abstract：:Obesity is a major public health concern and overconsumption of unhealthy fats and sugary beverages are contributing factors. Time-restricted feeding can reduce obesity-associated pathophysiological parameters by limiting the time of food consumption; however, the effects of time-restricted sugary water consumption ar...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.112905
更新日期：2020-09-01 00:00:00
abstract：:The effects of stress on risk assessment behavior in mice were studied by examining latency to emerge from a safe compartment into a large, well-lit open field. In the first experiment different groups of mice were exposed for 1 h to tube restraint, fixed interval 2-min foot shock, or attack by an aggressive conspecif...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02140-x
更新日期：1996-04-01 00:00:00
abstract：:This study analyzed in Balb/C mice the effects of individual housing on behavior, serum corticosterone and resistance to Ehrlich tumor growth. Mice (60 days old) were individually (IH) or grouped housed (G) (10-12 animals/cage) for 14-21 days. The 1st day of the housing condition was considered experimental day 1 (ED1...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.07.006
更新日期：2008-10-20 00:00:00
abstract：:Studies from this and other laboratories have demonstrated that sympathetic-adrenal medullary responses are reduced in laboratory rats exposed to chronic intermittent stress. To extend these findings, we have conducted three experiments in which laboratory rats were exposed daily for 26 consecutive days to the same (h...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90245-x
更新日期：1989-08-01 00:00:00
abstract：:Acutely infected animals show a set of non-specific behavioral changes known as sickness behavior. Recent studies have shown that occurrence of sickness behavior is regulated according to a motivational perspective. Thus, the display of sickness behavior may compete with display of other behaviors. In this work, we so...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.02.011
更新日期：2006-05-30 00:00:00
abstract：:Recent studies suggest that the decreased drinking response to hypertonic saline produced by bilateral subdiaphragmatic vagotomy (VGX) is a function of the route of saline administration and the length of postoperative recovery. We determined the effects of VGX on drinking during the two hours after intraperitoneal an...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90086-5
更新日期：1982-02-01 00:00:00
abstract：:The wavelength dependence of three different circadian responses to light was compared in Syrian hamsters: phase advances and phase delays induced by 15-min light pulses at CT18 (circadian time 18) and CT13, respectively, and changes in free-running period under different levels of constant illumination (LL) intensity...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00015-b
更新日期：1995-06-01 00:00:00
abstract：:Ovarian hormones have been shown to regulate liver lipid accumulation in rats. The present study was designed to evaluate liver lipid resorption in ovariectomized (Ovx) rats. Ovx and sham-operated (Sham) rats were submitted to a high-fat (HF; 43% kcal fat as energy) diet for 5 weeks and then either maintained on this ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.05.024
更新日期：2008-09-03 00:00:00
abstract：:The zebrafish has become increasingly utilized in behavioral neuroscience, psychopharmacology, and behavior genetics research. However, little attention has been paid to the potential effects of environmental conditions fish are exposed to before and during behavioral testing. One such important factor is temperature,...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113169
更新日期：2020-12-01 00:00:00
