Naloxone reversal of stress-induced suppression of LH release in the common marmoset.

Abstract:

:There is considerable evidence suggesting that endogenous opioid peptides (EOP) might play a role in the defensive response to stressful stimuli. The stress associated with receipt of aggression from a female conspecific and physical restraint for collection of serial blood samples (at 10-min intervals) resulted in a significant (p less than 0.05) suppression of LH secretion in the oestradiol primed ovariectomized marmoset. Administration of the opioid receptor antagonist, Naloxone (1 mg/kg) immediately before and after receipt of aggression completely prevented the stress-induced decrease in LH release. This suggests that EOP may mediate, at least in part, this stress induced decline in LH release in the marmoset.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

O'Byrne KT,Lunn SF,Dixson AF

doi

10.1016/0031-9384(89)90241-2

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

1077-80

issue

5

eissn

0031-9384

issn

1873-507X

pii

0031-9384(89)90241-2

journal_volume

45

pub_type

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