Abstract：
:In earlier work, we found that following lipopolysaccharide (LPS) injection at an ambient temperature (Ta) of 23 degrees C, old rats developed blunted fevers compared with those of young rats. However, the old rats did become febrile if placed in a thermally graded alleyway: they spent more time in the warm end of the gradient and developed a significantly higher body temperature (Tb) than they did following saline injections. In the present experiments, we maintained old and young rats for 3 days at 20 or 31 degrees C (the Ta preferred by the old rats given LPS). After LPS (50 microg/kg ip), the young rats developed equivalent fevers at both Ta's. The old rats developed fevers that were equivalent to those of the young rats at 31 degrees C. At 20 degrees C, their fever was significantly lower. These results suggest that Ta plays a decisive role in the ability of old rats to mount febrile responses.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Peloso ED,Florez-Duquet M,Buchanan JB,Satinoff Edoi
10.1016/s0031-9384(03)00046-5subject
Has Abstractpub_date
2003-04-01 00:00:00pages
651-4issue
4-5eissn
0031-9384issn
1873-507Xpii
S0031938403000465journal_volume
78pub_type
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