Beta-thioglucose inhibits gold thioglucose lesions in the ventromedial hypothalamus.

Abstract:

:Gold thioglucose (GTG) has been known to be an obesity causing agent for over 40 years. GTG works by affecting dendrites in the mouse ventromedial hypothalamus (VMH) producing a permanent VMH lesion and subsequent hyperphagia and obesity. We have investigated the effect of beta-thioglucose (BTG), a glucose antimetabolite, on GTG-induced lesions in the VMH of mice. Twenty-eight female CF-1 mice were used in this study. Seven micron sections were made of the mouse VMH, mounted on glass slides, and stained with hematoxylin and eosin. A previous report of BTG action on GTG-induced lesions has not supported a competitive inhibition between these two drugs. Our data demonstrate that at 1/2 hour, 6 hours, and 12 hours post BTG, BTG completely inhibited GTG-induced lesions in the VMH.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Brown DF,McGuirk JP,Larsen SP,Minter SD

doi

10.1016/0031-9384(89)90005-x

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

369-72

issue

3

eissn

0031-9384

issn

1873-507X

pii

0031-9384(89)90005-X

journal_volume

46

pub_type

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