Abstract：
:Following cholinergic denervation of the hippocampal formation, via medial septal lesions, sympathetic fibers, originating from the superior cervical ganglia, grow into the hippocampus. Previous studies have demonstrated a detrimental effect of these fibers on recovery of a spatial-learning task in male but not female animals. In this study we assessed the role of circulating male sex hormones on the behavioral and biochemical effects of hippocampal sympathetic ingrowth (HSI). For the behavioral studies male Sprague-Dawley rats underwent either sham gonadectomy or gonadectomy and were taught a standard radial 8-arm maze task. Following attainment of criterion animals underwent one of three surgical procedures: sham surgery, MS lesions, MS lesions + ganglionectomy. MS lesions, regardless of the presence of HSI, were found to severely impair reacquisition of the task in both sham-gonadectomized and gonadectomized animals. As expected, in the sham-gonadectomized group, MSGx animals reacquired the task faster than the MS group. However, gonadectomy was found to block the detrimental effect of HSI on behavior. For the biochemical studies hippocampal norepinephrine (NE) and choline acetyltransferase (ChAT) were measured eight weeks after surgery in sham-gonadectomized and gonadectomized animals. MS lesions were found to significantly reduce the ChAT activity, regardless of circulating sex hormones. Gonadectomy was found to significantly reduce the level of NE associated with HSI, while having no effect on central NE in CON or MSGx animals. These studies suggest that circulating male sex hormones can influence both the behavioral and biochemical processes associated with HSI.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Harrell LE,Goyal M,Parsons DS,Peagler Adoi
10.1016/0031-9384(90)90291-bsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
507-13issue
4eissn
0031-9384issn
1873-507Xpii
0031-9384(90)90291-Bjournal_volume
48pub_type
杂志文章abstract：:Olfactory bulbectomy (OBX) is a well known screening model for depression. Panax quinquefolium (PQ) is known for its therapeutic potential against several psychiatric disorders. Nitric oxide (NO), an intercellular messenger has been suggested to play a crucial role in the pathogenesis of depression. The present study ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.02.037
更新日期：2014-04-22 00:00:00
abstract：:The effects of loratadine, a peripherally acting histamine (H1) antagonist, and methysergide, a serotonin (5-HT) antagonist, were evaluated in seven normal-weight, male research volunteers, participating in a placebo-controlled, double-blind, 17-day residential study. Participants received oral loratadine (10 or 20 mg...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/s0031-9384(98)00046-8
更新日期：1998-05-01 00:00:00
abstract：:Administration of the opioid agonist, morphine (1 and 10 mg X kg-1), resulted in significant, dose-dependent increases in the ingestive responses of food-deprived slugs, Limax maximus, and in the initiation of feeding in satiated animals. These effects could be blocked by the opiate antagonist, naloxone (1 mg kg-1), w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90045-3
更新日期：1984-11-01 00:00:00
abstract：:(-)-Hydroxycitric acid (HCA) reportedly promotes weight loss, in part, through suppression of hunger. However, this mechanism has never been evaluated in humans in a controlled study. Eighty-nine mildly overweight females were prescribed 5020-kJ diets for 12 weeks as part of a double-blind, placebo-controlled parallel...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0031-9384(00)00321-8
更新日期：2000-10-01 00:00:00
abstract：:Glycemic conditioning was investigated in four experiments in which insulin was administered to animals in particular stimulus contexts. Both hyperglycemic and hypoglycemic conditioned responses were obtained, with the directionality of the CR dependent upon which environmental complex was used as the CS. These bidire...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90376-7
更新日期：1984-10-01 00:00:00
abstract：:The wavelength dependence of three different circadian responses to light was compared in Syrian hamsters: phase advances and phase delays induced by 15-min light pulses at CT18 (circadian time 18) and CT13, respectively, and changes in free-running period under different levels of constant illumination (LL) intensity...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00015-b
更新日期：1995-06-01 00:00:00
abstract：:The effects of chronic administration of cocaine to pregnant rabbits on maternal seizures and on pregnancy outcome were studied. Cocaine (2, 3 or 4 mg/kg/injection) or saline was administered, I.V., twice daily, from gestation Day 8 (G8) to G29. There were no significant differences in maternal weight gain or pregnanc...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00170-4
更新日期：1997-09-01 00:00:00
abstract：:The effects of deafferentation of the vomeronasal, olfactory or both systems of male mice on ultrasonic vocalizations in response to a male or female stimulus were analyzed. Regardless of the technique used, disruption of the vomeronasal system led to consistent reductions in ultrasonic vocalizations. Each animal rece...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90097-x
更新日期：1982-01-01 00:00:00
abstract：:In the developing rodent, there is a period from about days 4 to 14 when the adrenal response to stress is either minimal or non-existent. This has been designated as the stress hyporesponsive period (SHRP). Numerous experiments have demonstrated that maternal factors are critical for the regulation of the pup's hypot...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/s0031-9384(01)00496-6
更新日期：2001-06-01 00:00:00
abstract：:High-fat diet-feeding increases body weight and adiposity in Syrian hamsters (Mesocricetus auratus), effects due in part to decreased energy expenditure. The effects of voluntary exercise- or cold exposure-induced increases in energy expenditure were examined in fat- or chow-fed, female Syrian hamsters. In Experiment ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90075-1
更新日期：1984-01-01 00:00:00
abstract：:Parasagittal knife cuts through the perifornical hypothalamus either medial or lateral to the fornix produced hyperphagia and obesity and altered the rat's ingestive responses to dilute glucose solutions. The lateral knife cut rats drank less dilute glucose solution under both nondeprived and food deprived conditions ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(75)90280-2
更新日期：1975-07-01 00:00:00
abstract：:In vertebrates, male-typical sexual behavior (MSB) is largely controlled by gonadal androgens, however, the mechanism of this control is believed to vary among species. During immediate activation MSB is tightly correlated with circulating levels of androgens, while the organization of MSB by a hormonal event at a spe...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.12.030
更新日期：2017-03-01 00:00:00
abstract：:The sense of taste uses a variety of discrete receptor mechanisms to identify nutrients and toxins. Information from receptors is arrayed along a dimension of physiological welfare, which serves as the organizing principle of the taste system. This, in turn, drives central physiological and neurochemical processes tha...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2011.04.016
更新日期：2011-07-25 00:00:00
abstract：:With the rising prevalence of obesity and related health problems increases, there is increased interest in the gastrointestinal system as a possible target for pharmacological or food-based approaches to weight management. Recent studies have shown that under normal physiological situations undigested nutrients can r...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2008.07.018
更新日期：2008-10-20 00:00:00
abstract：:To examine the functional relationships between the dorsal raphe nucleus and the septum in the inhibitory regulation of feminine sexual behavior in male rats, castrated male rats received destruction of the dorsal raphe nucleus (DRL), interruption of the septal outputs (ARD), or both DRL and ARD (DRL+ARD). All animals...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90278-x
更新日期：1994-07-01 00:00:00
abstract：:We studied the effects of injecting agonists of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) muscimol (GABA-A receptor agonist) and baclofen (GABA-B receptor agonist) in the medial preoptic area (MPOA) and neighboring brain regions, the bed nucleus of the stria terminalis (BNST), and lateral preoptic...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.08.048
更新日期：2006-01-30 00:00:00
abstract：:Monogenic non-syndromic obesity is characterized by severe early-onset obesity with abnormal eating behaviour and endocrine disorders. Genes contributing to these rare forms of obesity are mainly located in the leptin/melanocortin pathway, with typically an autosomal additive inheritance of obesity. The normal functio...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113134
更新日期：2020-12-01 00:00:00
abstract：:Aspartame (APM; L-aspartyl-L-phenylalanine methyl ester) was investigated for its ability to alter brain amino acids and monoamines in overnight fasted rats allowed to consume commercial diets for 60 minutes. In addition, the effects of mealing on the changes in plasma and brain amino acids and brain monoamines induce...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90365-3
更新日期：1986-01-01 00:00:00
abstract：:3,4-Methylenedioxymethamphetamine (MDMA) use has been associated with a decline in various aspects of mnemonic function in humans. We therefore postulated that MDMA-induced damage of serotonergic nerve terminals would alter hippocampal processing. Seven days following treatment with MDMA (2 x 20 mg/kg sc, given 12 h a...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(03)00092-1
更新日期：2003-07-01 00:00:00
abstract：:Schizophrenia patients show a high rate of premature mortality due to suicide. The pathophysiological mechanisms of these suicidal behaviors in schizophrenia do not appear to involve serotonergic neurotransmission as found in the general population. Our aim was to develop an in vivo model of schizophrenia presenting s...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.01.002
更新日期：2016-03-15 00:00:00
abstract：:To investigate the role of gastric contractility in the prepyloric control of meal size, we administered atropine methyl nitrate (3 mg/kg,ip) or saline prior to 30-min tests on 3 separate days in which 0.8 M sucrose was ingested by rats after 1 h of food deprivation. Ingested 0.8 M sucrose accumulated in the stomach a...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02132-9
更新日期：1996-02-01 00:00:00
abstract：:Osmoregulatory mechanisms can be vulnerable to electrolyte and/or endocrine environmental changes during the perinatal period, differentially programming the developing offspring and affecting them even in adulthood. The aim of this study was to evaluate whether availability of hypertonic sodium solution during the pe...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.11.015
更新日期：2012-02-28 00:00:00
abstract：:We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/Pl) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM ra...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02109-4
更新日期：1996-03-01 00:00:00
abstract：:Fluoride ingestion has been linked to changes in behavior in mice and rats, related to dose, sex of the animal, and the timing of exposure. Previous studies have shown the behavior of female rats to be most affected by postnatal fluoride exposure, and in this study we determined the effects of postnatal fluoride expos...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.02.017
更新日期：2019-07-01 00:00:00
abstract：:Male rats were punished (0.6 mA/2 sec) for entering the shock compartment of a passive avoidance chamber. Twenty four hours later they were returned to the apparatus and confined to the grid floor of the shock compartment for 5 min (forced exposure). The bradycardic response found in control rats during forced exposur...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：:We have demonstrated previously that the use of an across-session progressive ratio procedure yields breakpoint values for 10% ethanol (10E) that are stable and comparable to those measured for other drugs of abuse [Alcohol. Clin. Exp. Res. 23 (1999) 1580]. The aims of the present experiment were twofold: (1). to dete...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00963-0
更新日期：2003-01-01 00:00:00
abstract：:Bombesin, an analog to gastrin releasing peptide, has previously been shown to inhibit food intake in the rat. In order to further characterize the effects of bombesin on ingestive behavior, the present study examined licking patterns of rats drinking sweetened condensed milk following bombesin (4 micrograms/kg, IP) o...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90384-r
更新日期：1993-06-01 00:00:00
abstract：:The present study was designed to characterize and assess the reliability of acute mood responses to maximal exercise in women. All subjects (N = 22; age = 45 +/- 2.5 yr; BMI = 24.3 +/- 0.9 kg/m2) participated in two maximal walking tests spaced approximately one month apart. The abbreviated Profile of Mood States (PO...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00195-b
更新日期：1995-01-01 00:00:00
abstract：:Pine voles (Microtus pinetorum) were given sipper tubes containing saccharin solution, and after drinking, were injected with 0.15 M LiCl. Subsequently, two-sipper tests were given to assure the presence of conditioned flavor avoidance (CFA), and then animals were presented with saccharin in carboxymethyl-cellulose on...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90269-0
更新日期：1985-12-01 00:00:00
abstract：OBJECTIVE:Antipsychotic (AP) drugs frequently induce weight gain. The present study aimed at exploring a potential association between antipsychotic-induced weight gain and delayed negative alliesthesia for sweet stimuli. RESEARCH METHODS AND PROCEDURES:The study aimed at recruiting patients undergoing AP treatment, h...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/j.physbeh.2008.05.013
更新日期：2008-09-03 00:00:00
