Abstract:
:Aspartame (APM; L-aspartyl-L-phenylalanine methyl ester) was investigated for its ability to alter brain amino acids and monoamines in overnight fasted rats allowed to consume commercial diets for 60 minutes. In addition, the effects of mealing on the changes in plasma and brain amino acids and brain monoamines induced by glucose and/or insulin, and known pharmacologically active compounds, were studied. The consumption of the commercial chow largely prevented changes in blood glucose and amino acids, and brain amino acids and the monoamines dopamine, norepinephrine and serotonin that might be expected to occur following glucose with or without insulin. Feeding failed to prevent changes in the above parameters when 5-hydroxy-tryptophan, p-chlorophenylalanine and reserpine were administered. The oral administration of up to 250 mg/kg BW APM with water or glucose followed by free feeding failed to alter brain monoamines. These studies demonstrate the potent ability of food to normalize biochemical parameters in blood and brain that otherwise might occur, and clearly show the lack of effect on brain monoamine levels of abuse doses of APM when administered with food.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Torii K,Mimura T,Takasaki Y,Ichimura Mdoi
10.1016/0031-9384(86)90365-3subject
Has Abstractpub_date
1986-01-01 00:00:00pages
759-64issue
4eissn
0031-9384issn
1873-507Xpii
0031-9384(86)90365-3journal_volume
36pub_type
杂志文章abstract::One group of male rats was reared continuously in small, stable colonies of three animals each during a ten-week period beginning when they were 46 days old. A second group of animals was also reared in small groups of three animals each but membership within these colonies was randomly changed at weekly intervals. Th...
journal_title:Physiology & behavior
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abstract::The current study examines the effects of electrolytic median raphe lesions on the feeding and drinking behaviors of rats maintained on a 23-hr food deprivation schedule. Measurement of food intake during the feeding period indicated no difference between the two groups but lesioned animals showed significantly more s...
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abstract::Male mice, genetically selected for aggression, characterized by short attack latency (SAL) or long attack latency (LAL), differ on several testosterone (T)-related parameters during ontogeny and adult age. The variation in aggressive behavior at adult age may be due to differences in degree of androgenization prenata...
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更新日期:1993-11-01 00:00:00
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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更新日期:2016-08-01 00:00:00
abstract::Toddler's diarrhea may be an allergic disease and its recurrences can be avoided with education to "internal spontaneity" in feeding, i.e., by education to a limited and reproducible decrease in eating incentives at the onset of meals. Serum IgE was thus investigated in 16 experimental children in a random comparison ...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章,评审
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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更新日期:1982-04-01 00:00:00
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journal_title:Physiology & behavior
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更新日期:1990-03-01 00:00:00
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journal_title:Physiology & behavior
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更新日期:1997-08-01 00:00:00
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-02-15 00:00:00
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journal_title:Physiology & behavior
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更新日期:1986-01-01 00:00:00
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更新日期:1994-03-01 00:00:00
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更新日期:1997-05-01 00:00:00
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journal_title:Physiology & behavior
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更新日期:2008-10-20 00:00:00
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更新日期:1992-01-01 00:00:00
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journal_title:Physiology & behavior
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