Abstract：
:Disruption in the gut microbiota is now recognized as an active contributor towards the development of obesity and insulin resistance. This review considers one class of dietary additives known to influence the gut microbiota that may predispose susceptible individuals to insulin resistance - the regular, long-term consumption of low-dose, low calorie sweeteners. While the data are controversial, mounting evidence suggests that low calorie sweeteners should not be dismissed as inert in the gut environment. Sucralose, aspartame and saccharin, all widely used to reduce energy content in foods and beverages to promote satiety and encourage weight loss, have been shown to disrupt the balance and diversity of gut microbiota. Fecal transplant experiments, wherein microbiota from low calorie sweetener consuming hosts are transferred into germ-free mice, show that this disruption is transferable and results in impaired glucose tolerance, a well-known risk factor towards the development of a number of metabolic disease states. As our understanding of the importance of the gut microbiota in metabolic health continues to grow, it will be increasingly important to consider the impact of all dietary components, including low calorie sweeteners, on gut microbiota and metabolic health.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Nettleton JE,Reimer RA,Shearer Jdoi
10.1016/j.physbeh.2016.04.029subject
Has Abstractpub_date
2016-10-01 00:00:00pages
488-493issue
Pt Beissn
0031-9384issn
1873-507Xpii
S0031-9384(16)30164-0journal_volume
164pub_type
杂志文章,评审abstract：:A binge drinking pattern of alcohol consumption has been shown to have an impact on brain structures that continue to develop into late adolescence. These same brain structures have been implicated in processing self-movement cues. The current study applies an array of existing and novel kinematic analysis techniques ...
journal_title：Physiology & behavior
pub_type： 杂志文章
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abstract：:A novel model to evaluate erectile, ejaculatory, and sexual behavior patterns in conscious mouse is presented. Corpus spongiosum of the penis (CSP) pressure was recorded by using telemetry and was correlated with erectile activity (penile elongations, cups, flips) during reflex induction and spontaneous erections in f...
journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2007-08-15 00:00:00
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2007.11.051
更新日期：2008-03-18 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1997-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2005-07-21 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90242-v
更新日期：1990-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
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更新日期：1993-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.02.003
更新日期：2005-03-31 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.11.011
更新日期：2005-03-16 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2007-06-08 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2006-06-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2009-01-08 00:00:00
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1997-08-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1983-04-01 00:00:00
