Abstract：
:Angiotensins, especially angiotensin IV (Ang IV), have recently been found to be potent cognitive enhancers in rodents. However, the precise mechanisms of their memory improving effects remain unknown. In this study we tested the hypothesis that D2 dopamine receptors at least partially mediate cognitive effects of Ang IV and its derivative des-Phe6 Ang IV. Namely, the well known cognitive effects of both peptides [facilitation of a conditioned avoidance responses (CARs) acquisition, increase of a passive avoidance behavior (PAB) retrieval, and improvement of object recognition] were evaluated in rats either pretreated or not with a selective D2 dopamine receptor antagonist remoxipride {(S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylOmethyl]2,6-dimethoxybenzamide hydrochloride}. To control for the unspecific motor and emotional effects of our treatments that could confound results of the memory tests we used respectively, 'open' field and elevated 'plus' maze tests. Ang IV as well as des-Phe6 Ang IV remarkably improved learning of CARs, recall of PAB and recognition of the previously seen objects. D2 receptors blockade by remoxipride abolished all these effects of both peptides. In the elevated 'plus' maze remoxipride abolished anxiogenic effects of both Ang IV and des-Phe6 Ang IV. Also, the drug followed by Ang IV decreased number of crossings and by des-Phe6 Ang IV number of crossings and rearings. The results point to importance of the functional D2 dopamine receptors in cognitive effects of Ang IV and its naturally occurring product devoid of C-terminal Phe6.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Braszko JJdoi
10.1016/j.physbeh.2006.03.025subject
Has Abstractpub_date
2006-06-15 00:00:00pages
152-9issue
1-2eissn
0031-9384issn
1873-507Xpii
S0031-9384(06)00130-2journal_volume
88pub_type
杂志文章abstract：:Young-adult, female Binghamton Heterogeneous Stock (HET) mice either were exposed to lead via drinking water from birth, or not. Eight days after giving birth to their first litter of pups (at about 70-75 days of age), postpartum aggression tests were conducted. Unfamiliar Het male intruders were introduced to the pri...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90053-x
更新日期：1989-11-01 00:00:00
abstract：OBJECTIVE:Electroacupuncture (EA) as well as moxibustion stimulation has been reported to produce an excitatory effect on the gastrointestinal motility of the rat. Serotonergic neurons of the mioenteric and submucous plexus are major participants in the gastrointestinal physiology. Here, we compared the outcomes of the...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.07.003
更新日期：2004-10-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90128-7
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:The possible factors related to functional impairment and limitations in patients with temporomandibular disorders (TMDs) still need to be clarified because recovery of orofacial functions is a goal of their treatment. OBJECTIVE:To investigate whether chronic TMD patients had any changes in tongue strength,...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112616
更新日期：2019-10-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90197-x
更新日期：1994-08-01 00:00:00
abstract：:Injection of clonidine or methyldopa in rats immediately after daily two-hour exposure to a complex environment (EC) reduced the increase in occipital cortical weight normally associated with such exposure in comparison with animals kept in isolation. Drug injection four hours after EC exposure had no effect. Drug ind...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90053-7
更新日期：1983-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2011.05.002
更新日期：2011-09-26 00:00:00
abstract：:Some apparently healthy male rats fail to copulate despite being tested on repeated occasions with receptive females and are called non copulating (NC) rats. NC rats sniff and lick the female genitals, and show normal erectile and ejaculatory functions and hormonal levels. Sexually sluggish (S) male rats take a long t...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.11.027
更新日期：2008-03-18 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90088-7
更新日期：1989-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90064-7
更新日期：1984-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.11.029
更新日期：2015-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90267-7
更新日期：1985-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90194-9
更新日期：1982-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90278-x
更新日期：1994-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90343-9
更新日期：1985-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2007.11.018
更新日期：2008-04-22 00:00:00
abstract：:In investigating the ability of the rat to discriminate among urine odors from mice of different genetic strains, we developed a technique for determining the extent of odor generalization. Trained rats performed a discrete trial, go/no-go procedure, touching a bar in the presence of an S+ odor for water reward. Rats ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90357-8
更新日期：1992-09-01 00:00:00
abstract：:Glucagon-like peptide 2 (GLP-2), a member of Glucagon peptide family involved in regulating energy metabolism, can be produced and secreted by preproglucagonergic (PPG) neurons in the brain. GLP-2 reduces food intake but at which brain sites GLP-2 exerts its feeding-suppress effects are still unclear. In this study, w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113253
更新日期：2021-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/s0031-9384(01)00496-6
更新日期：2001-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90182-f
更新日期：1993-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90175-2
更新日期：1992-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/0031-9384(93)90095-w
更新日期：1993-10-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0031-9384(98)00169-3
更新日期：1998-11-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.11.041
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Sex may influence the relationship between HPA axis functioning and obesity. This has been suggested to be due to sex-specific differences in body composition, body fat distribution and psychological variables. Age and the use of oral contraceptives may also influence the relationship between HPA axis functi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.02.016
更新日期：2012-05-15 00:00:00
abstract：:Currently, there are no effective pharmacological therapies for chronic tinnitus despite a number of efforts from clinical studies and more recently, studies in animals using compounds to enhance endogenous inhibition or reduce central hyperactivity. The purpose of the current study was to evaluate the therapeutic eff...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.05.022
更新日期：2011-10-24 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.01.011
更新日期：2006-04-15 00:00:00
abstract：:It has been recognized for some time that a number of different neuropeptides exert powerful effects on food intake. During the last few years, the neurocircuitry within which these peptides operate has also begun to be elucidated. Peptidergic feeding-regulatory neurones are found both in the hypothalamus and the brai...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/s0031-9384(01)00611-4
更新日期：2001-11-01 00:00:00
abstract：:The aim of this study was to evaluate the impact of knowledge-based work (KBW) on feeding behavior and spontaneous energy intake with the use of a repeated measures/within-subjects design. We used a two-session protocol including an ad libitum buffet preceded by either rest in a sitting position for 45 min or a cognit...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.08.030
更新日期：2007-01-30 00:00:00
abstract：:Stocking density is considered a stress factor for fish and is therefore one of the numerous concerns about fish welfare in an aquaculture context. Stress coping styles (SCS) are defined as a coherent set of individual physiological and behavioral differences in stress responses that are consistent across time and con...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112698
更新日期：2019-12-01 00:00:00
