Hypothalamic and vagal neuropeptide circuitries regulating food intake.

Abstract:

:It has been recognized for some time that a number of different neuropeptides exert powerful effects on food intake. During the last few years, the neurocircuitry within which these peptides operate has also begun to be elucidated. Peptidergic feeding-regulatory neurones are found both in the hypothalamus and the brainstem, where they act as input stations for hormonal and gastrointestinal information, respectively. These cell populations both project to several other brain regions and interconnect extensively. The present review summarizes the neuroanatomy and connectivity of some prominent peptides involved in food intake control, including neuropeptide Y, melanocortin peptides, agouti gene-related protein, cocaine- and amphetamine-regulated transcript, orexin/hypocretin, melanin-concentrating hormone and cholecystokinin. Disturbances in the hypothalamic neuropeptide systems have been implicated in the phenotype of a genetic model of fatal hypophagia, the mouse anorexia (anx) mutation, which is also discussed.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Broberger C,Hökfelt T

doi

10.1016/s0031-9384(01)00611-4

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

669-82

issue

4-5

eissn

0031-9384

issn

1873-507X

pii

S0031938401006114

journal_volume

74

pub_type

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