Cholecystokinin, but not bombesin, has interoceptive sensory consequences like 1-h food deprivation.

Abstract:

:A comparison of the interoceptive sensory consequences of cholecystokinin, bombesin, and 1-h food deprivation was conducted in rats. In two experiments, rats were first trained to use stimuli arising from different degrees of food deprivation (1 and 24 h or 1 and 4 h) as discriminative signals for shock, and were then tested for generalized control of discriminative responding (i.e., conditioned freezing) by cues arising from injection of 4 micrograms/kg (Experiment 1 only) and 8 micrograms/kg cholecystokinin (Experiment 1A only), 12 micrograms/kg bombesin (BBS), and isotonic saline, respectively. The effects of these peptides on food intake were also assessed. In both experiments, BBS and cholecystokinin (CCK) each suppressed feeding relative to saline; however, generalization of discriminative responding was obtained only following CCK. Generalization depended on prior learning about food deprivation cues--CCK had little effect on freezing in rats that showed weak discrimination performance (i.e., rats trained with 1- and 4-h deprivation cues). The results indicated that CCK but not BBS produces interoceptive cues like those occurring under 1-h food deprivation.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Davidson TL,Carretta JC

doi

10.1016/0031-9384(93)90182-f

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

737-45

issue

4

eissn

0031-9384

issn

1873-507X

pii

0031-9384(93)90182-F

journal_volume

53

pub_type

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