Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine.

Abstract:

:Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine. These rats displayed enhanced intragroup aggression but normal muricide; gustatory neophobia and conditioned taste aversion were virtually eliminated. Severe working and reference memory deficits were evident within the radial arm maze. Both state-dependent memory and possible situation-dependent precipitation of spontaneous seizures were suggested. The behavioral changes were considered commensurate with the multifocal pattern of thalamic, hippocampal/amygdaloid, and limbic cortical damage.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Persinger MA,Bureau YR,Kostakos M,Peredery O,Falter H

doi

10.1016/0031-9384(93)90261-d

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

849-66

issue

5

eissn

0031-9384

issn

1873-507X

pii

0031-9384(93)90261-D

journal_volume

53

pub_type

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