Abstract：
:The aim of the present study with rats was to show that electrical stimulation of a monosynaptic pathway, whose high plastic potency is well-known, can serve as a conditioned stimulus (CS) in a learning paradigm. Using chronic rats, stimulation of the perforant pathway, which activates the entorhinal cortex input to the dentate gyrus of the hippocampus, was used as the CS in a footshock motivated two-way avoidance task (shuttle box). Among the different stimulation parameters tested, only trains of at least 15 Hz were shown to be effective as a CS, whereas the application of single impulses with a frequency of 1,7 Hz did not result in the establishment of conditioned behavior. Using the 15 Hz-paradigm, in "good learners," the development of reliable conditioned responses started at the end of the first training session (40 trials) and become fairly stable during a further training session, given on the following day. The application of stimulation trains with 100 Hz as a CS led to the development of a high rate of conditioned responses, however, there was also a high level of intertrial reactions. Considering the critical importance of the frequency parameters of the perforant pathway stimulation for the development of conditioned behavior the possible involvement of hippocampal long-term potentiation in behavioral plasticity is discussed. Additionally, it is concluded that this new learning paradigm offers the advantage of concurrent analysis of plastic processes both at the behavioral level and at the level of the synaptic population.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Reymann KG,Rüthrich H,Lindenau L,Ott T,Matthies Hdoi
10.1016/0031-9384(82)90291-8subject
Has Abstractpub_date
1982-12-01 00:00:00pages
1007-12issue
6eissn
0031-9384issn
1873-507Xpii
0031-9384(82)90291-8journal_volume
29pub_type
杂志文章abstract：:Four groups of pigeons each were trained to perform four visual-discrimination tasks of varying difficulty. Two groups received the training binocularly and the other two monocularly. Two types of stimulus displays were used. In one display the two pecking keys were mounted in a horizontal arrangement, whereas, in the...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90204-x
更新日期：1984-05-01 00:00:00
abstract：:As the best-studied form of vertebrate synaptic plasticity, NMDA-receptor dependent long-term potentiation (NMDAR-LTP) has long been considered a leading candidate for a cellular locus for some aspects of learning and memory. However, assigning a specific role for this form of plasticity in learning and memory has pro...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/s0031-9384(01)00514-5
更新日期：2001-08-01 00:00:00
abstract：:Intraperitoneal injections of the opiate antagonist naloxone decreased food intake in both vagotomized and sham-vagotomized rats. Consumption of liquid and solid sucrose, which were used in order to equate baseline intake, was equally suppressed in both groups under food-deprivation and appetitively-motivated conditio...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90345-6
更新日期：1982-11-01 00:00:00
abstract：:This report describes a standard procedure for studying the disordered eating behavior of bulimic patients in a laboratory setting. Test meals were given to eight normal weight women with bulimia under four different conditions on non-consecutive days. On day 1 they were asked to consume as much as they "would normall...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90426-9
更新日期：1986-10-01 00:00:00
abstract：:Certain popular models of the regulation of food intake predict a positive correlation between the size of a meal and the preceding and/or following intermeal interval. However, the reported strength of these prandial correlations has varied widely in the literature. To determine what factors may influence the strengt...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(99)00086-4
更新日期：1999-09-01 00:00:00
abstract：:It has been shown that acquisition rates in the water maze vary across strains of mice, although the differential effects of previous experience in this spatial task have been scarcely evaluated. The aim of the present study was to evaluate the effects of training in the water maze at an early age (2 months) in two st...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(99)00059-1
更新日期：1999-08-01 00:00:00
abstract：:Based upon his work with robots, Raibert proposed that a specific class of symmetry equations may be important to animals and humans during steady-state running. In a test of this hypothesis, Raibert found good agreement with his predictions. However, his test was limited to one cat at two speeds and a human at a sing...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90334-x
更新日期：1989-10-01 00:00:00
abstract：:The arcuate nucleus of the hypothalamus, a highly sexually dimorphic brain region, has been called the bed nucleus for endogenous opioids. The potential contribution of opioids in this nucleus to modulate control of ventilation in male and female rats has not been investigated. The purpose of the present study is to d...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)80330-7
更新日期：1997-09-01 00:00:00
abstract：:Eight obese patients (exceeding ideal body weight by 50% or more) with no endocrinological or metabolic disorders and 8 healthy, age-matched, normal-weight volunteers were submitted to an overnight short dexamethasone (DXM) suppression test and to a psychological assessment through various psychometric scales. Plasma ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90456-7
更新日期：1986-01-01 00:00:00
abstract：:Food intake and gastric emptying were measured simultaneously after cholecystokinin-octapeptide (CCK-8) and saline infusions in order to test the hypothesis that reduction in gastric emptying mediates the effect of CCK-8 on food intake. Each of twelve nonobese healthy men received intravenous infusions of CCK-8 and sa...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90330-7
更新日期：1988-01-01 00:00:00
abstract：:The aims of this study were 1) to describe the effects of a 54 km and 111 km ultra-endurance mountain race on the biomarkers of muscle damage and inflammation, 2) to compare the effects between the two races regarding the biomarkers of muscle damage and inflammation. Sixteen ultra-endurance amateur runners volunteered...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.10.002
更新日期：2019-06-01 00:00:00
abstract：:Patients suffering from depression-associated cognitive impairments often recover incompletely after remission from the core symptoms of depression (lack of energy, depressed mood and anhedonia). This study aimed to set the basis for clinically relevant testing of cognitive impairments in a preclinical model of depres...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.11.010
更新日期：2018-02-01 00:00:00
abstract：:Micrencephalic offspring produced by gestational treatment with the antimitotic compound/methylazoxymethanol acetate (MAM) are remarkable for substantial preservation of function concurrent with severe neural stunting. Altered behaviors in these micrencephalics, including light shyness and response perseveration, are ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00154-b
更新日期：1995-11-01 00:00:00
abstract：:Previous studies suggest that binge eating sugar leads to behavioral and neurochemical changes similar to those seen with drug addiction, including signs of opiate-like withdrawal. Studies are emerging that show multiple neurochemical and behavioral indices of addiction when animals overeat a fat-rich diet. The goal o...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.05.018
更新日期：2011-10-24 00:00:00
abstract：:For a given fish species, individuals are different in their ability to cope with stressors; each individual has its own set of physiological and behavioral responses to stress (stress-coping style). This individual diversity is of importance when considering the welfare of fish reared in aquaculture facilities. In th...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112576
更新日期：2019-09-01 00:00:00
abstract：:The effects of immediate posttraining subcutaneous administration of naloxone (0.25, 1 or 5 mg/kg) on retention behaviour of rats trained in an inhibitory avoidance task, subjected or not to familiarization with the training situation prior to the training trial (pretraining) have been investigated. Naloxone did not i...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90394-4
更新日期：1985-11-01 00:00:00
abstract：:This study was undertaken to investigate changes in ambulatory and drinking behavior, using the Gunma University-type special apparatus for continuous and direct measurement of ambulation and drinking in streptozotocin-induced diabetic rats (STZ, 60 mg/kg). Ambulatory activity of diabetic rats was significantly less t...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90366-c
更新日期：1990-06-01 00:00:00
abstract：:Experiments were performed to measure the influence of centrally and peripherally applied arginine vasopressin (AVP) on anxiety-related behavior as indicated by the elevated plus maze test. Central administration was performed into the septum using a microdialysis technique. In initial experiments, the microdialysis p...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00119-x
更新日期：1998-06-15 00:00:00
abstract：:The research literature suggests that oxidative stress and pro-inflammatory factors influence neurotrophins in vitro. However, there is insufficient information about their effects on exercise training conditions, especially during high intensity trainings. This study aimed to compare the effects of 6weeks of high int...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.04.012
更新日期：2015-08-01 00:00:00
abstract：:The acquisition of active avoidance response was studied in rats injected intracerebroventricularly with calcitonin (CT), parathyroid hormone (PTH) or PTH-related fragments. PTH and PTH65-84 facilitated the acquisition of shuttle-box active avoidance behavior as indicated by the number of conditioned avoidance respons...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90228-2
更新日期：1984-12-01 00:00:00
abstract：:The use of heart rate variability (HRV) for monitoring stress has been growing in the behavioral health literature, especially in the areas of posttraumatic stress disorder, stress reactivity, and resilience. Few studies, however, have included general populations under workplace conditions. This study evaluates wheth...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112734
更新日期：2020-02-01 00:00:00
abstract：:Behavioral and physiological consequences of heparinoid injections, which increase plasma levels of nonesterified fatty acids (NEFA) by releasing lipoproteinlipase into the circulation, were studied in rats, because, according to the lipostatic hypothesis of food intake control, changes in plasma metabolite levels sho...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90046-x
更新日期：1983-01-01 00:00:00
abstract：:The influences of three methyl xanthines (MX) on human taste responsivity, caffeine, theophylline, and theobromine, were examined using blind control procedures. Taste responsivity in the same subjects was determined using the matching procedure described by Schiffman (Study 1) and the whole-mouth procedure described ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90347-5
更新日期：1992-09-01 00:00:00
abstract：:Currently, two gaps exist in the study of early stress response caused by maternal separation (MS) in rodents. Firstly, the influence of brief maternal separation (less than 1 hour) on physiological and behavioral development of offspring is still largely unexplored despite its fundamental and applied value. Secondly,...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.112877
更新日期：2020-08-01 00:00:00
abstract：:Bulbectomy has been previously shown to produce the specific antidepressant-sensitive syndrome in C57Bl/6j, but not DBA/2j mice. The present study examined the effect of the depression on voluntary alcohol consumption. Alcohol consumption and alcohol preference (% of alcohol solution in total liquid) in a free-choice,...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90293-3
更新日期：1994-09-01 00:00:00
abstract：:Pleasant and unpleasant flavors and odors can modulate pain perception, and the efficacy of sweet flavors in reducing pain seems to be related to its hedonic value. Chronic variate stress paradigm is a model of depression, and is suggested to induce anhedonia. We observed previously that lithium may prevent behavioral...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.04.004
更新日期：2006-07-30 00:00:00
abstract：:A binge drinking pattern of alcohol consumption has been shown to have an impact on brain structures that continue to develop into late adolescence. These same brain structures have been implicated in processing self-movement cues. The current study applies an array of existing and novel kinematic analysis techniques ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.04.027
更新日期：2016-07-01 00:00:00
abstract：:An experimental model was developed to measure various behavioral and physiological parameters in a laboratory paradigm mimicking phase shifts that could occur in time-zone transitions and shift work rotas. Volunteers were exposed to 9-h pulses of bright light (1,200 lx) as follows: day (D)1: 1800-0300 h, D2: 2100-060...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/0031-9384(95)02147-7
更新日期：1996-04-01 00:00:00
abstract：:Daily rhythms in glucose tolerance have been reported for several species of mammals, which seem to be linked to factors such as daily rhythms of insulin resistance and feeding habits. In this paper, we studied entrainment to a daily scheduled meal of blood glucose after carbohydrate intake (dextrin or glucose). After...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.12.015
更新日期：2009-03-23 00:00:00
abstract：:The effects of postnatal protein malnutrition on juvenile social behaviors were investigated in male and female Wistar rats. During the lactation period (21 days), each litter (six male and two female pups) was provided with 16% (control) or 6% (low protein) casein diets. At weaning, the control group (W) continued to...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00554-6
更新日期：2001-09-01 00:00:00
