Effects of early postnatal gonadal steroids on extinction of a continuously food-rewarded running response.

Abstract:

:In the present work the existence of sex differences (Experiment 1) on the acquisition and extinction of a continuously reinforced response in a short and narrow runway (100 x 9 x 10 cm) were investigated. In addition to the investigation of the basic sex differences in Experiment 1, the effect of postpuberal gonadectomy of male and female rats and the role of the early postnatal gonadal steroids on these situations were also examined in Experiments 2 and 3, respectively. In all experiments, no sex differences were found in acquisition. However, males extinguished faster than female rats. Gonadectomy of both sexes in adulthood, although it increases their latencies in acquisition, did not affect the differences between sexes during extinction. In contrast, in Experiment 3 female androgenization and male orchidectomy on day one after birth reversed the direction of sex differences found between control rats in the extinction period. Our findings suggests that the observed sex differences in extinction may be due to an underlying sexual dimorphism in the response inhibition process.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Enriquez P,Calés JM,Sánchez-Santed F,Guillamón A

doi

10.1016/0031-9384(91)90230-l

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

57-61

issue

1

eissn

0031-9384

issn

1873-507X

pii

0031-9384(91)90230-L

journal_volume

49

pub_type

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