Effects of pyruvate and lactate on food intake in rat strains sensitive and resistant to dietary obesity.

Abstract:

:We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/Pl) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM rats and these effects were blocked by selective hepatic vagotomy. In contrast, in S5B/Pl rats fed an LF diet the responses to pyruvate and lactate were attenuated and were absent in S5B/Pl rats fed the HF diet. These data suggest that OM and S5B/Pl rats differ either in their metabolism of pyruvate and lactate or in their responses to these metabolites.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Nagase H,Bray GA,York DA

doi

10.1016/0031-9384(95)02109-4

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

555-60

issue

3

eissn

0031-9384

issn

1873-507X

pii

0031-9384(95)02109-4

journal_volume

59

pub_type

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