Abstract:
:Marked increases in anxiety-like responses to stress occur during pregnancy. Considerable evidence indicates that the basolateral region of the amygdala (BLA) plays an important role in mediating these types of responses. Given the crucial inhibitory influence of GABA on excitatory glutamatergic activity in the BLA, we hypothesized that decreased GABAergic activity in this region may underlie the increased anxiety associated with pregnancy. In vivo microdialysis was used to sample extracellular GABA before and after 30 min of restraint stress. While there was no detectable effect of restraint on extracellular GABA concentrations, basal GABA levels were significantly decreased in pregnant rats compared with either virgin females or males. We suggest that the alterations in anxiety-like behavior that occur during pregnancy may be associated with decreased basal GABA in the BLA.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Young BJ,Cook CJdoi
10.1016/j.physbeh.2006.01.011subject
Has Abstractpub_date
2006-04-15 00:00:00pages
817-20issue
4eissn
0031-9384issn
1873-507Xpii
S0031-9384(06)00035-7journal_volume
87pub_type
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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更新日期:2012-06-25 00:00:00
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章,评审
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更新日期:1991-05-01 00:00:00
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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更新日期:2006-08-30 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1989-10-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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