Abstract：
:Glucagon-like peptide 2 (GLP-2), a member of Glucagon peptide family involved in regulating energy metabolism, can be produced and secreted by preproglucagonergic (PPG) neurons in the brain. GLP-2 reduces food intake but at which brain sites GLP-2 exerts its feeding-suppress effects are still unclear. In this study, we used the stereological microinjection technique and behavioral test to examine the functions of locally delivered GLP-2 into DMH on feeding behavior. We compared effects of different concentration of GLP-2 on the food intake behavior in free-feeding rats and fasted-refeeding rats. We found that GLP-2 inhibited food intake in fasted rats after a short-term intervention in a dose-dependent manner. Importantly, the effects of locally delivered GLP-2 can be blocked by specific GLP-1 receptor antagonist Exendin(9-39), but not the melanocortin-4 receptor antagonist SHU9119, indicating the involvement of specificity of GLP-2 signaling in regulating the feeding behavior. Taken together, our data revealed that GLP-2 peptide pharmacologically inhibited food intake in DMH and this effect could be blocked functionally by Exendin(9-39).
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Sun H,Meng K,Hou L,Shang L,Yan Jdoi
10.1016/j.physbeh.2020.113253subject
Has Abstractpub_date
2021-02-01 00:00:00pages
113253eissn
0031-9384issn
1873-507Xpii
S0031-9384(20)30567-9journal_volume
229pub_type
杂志文章abstract：:Others have shown that frontally dominant EEG activity of around 7-8 Hz is linked to ongoing cognitive performance. Interestingly, we have found that this EEG activity is particularly evident during the relatively artefact-free period following "lights out" at bedtime when people report "thinking" when lying relaxed i...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/j.physbeh.2004.03.006
更新日期：2004-06-01 00:00:00
abstract：:Acetyl-l-carnitine (ALC), a natural component of several biological systems, has been found to modify spontaneous and evoked electrocortical activity in young rats and to improve learning ability in old ones. In clinical application it also improves mood and attention in elderly patients. The present study was aimed a...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90060-1
更新日期：1988-01-01 00:00:00
abstract：:Early overnutrition disrupts leptin sensitivity and the development of hypothalamic pathways involved in the regulation of metabolism and feeding behavior. While previous studies have largely focused on the development of neuronal projections, few studies have examined the impact of early nutrition on hypothalamic syn...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.04.002
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVES:To seek insights into the relationship between chewing, appetite, food intake and gut hormones, and to consider potentially useful recommendations to promote benefits of chewing for weight management. MATERIALS AND METHODS:Papers were obtained from two electronic databases (Medline and Cochrane), from searc...
journal_title：Physiology & behavior
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.physbeh.2015.07.017
更新日期：2015-11-01 00:00:00
abstract：:Communal nesting (CN) is a mouse model of early social enrichment during pregnancy and lactation. In this study, a rat model of CN was developed to determine if CN exerts an epigenetic effect in rats selectively bred for an infantile affective trait (high and low rates of ultrasonic distress calls). High and Low offsp...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.11.007
更新日期：2015-02-01 00:00:00
abstract：:The influence of metabolic status on food selection during refeeding after fasting was investigated in rats fasted for a long period of time and subsequently given the choice of eating fat, protein, and carbohydrate individually. Rats were fasted until either metabolic phase 2 (essentially using lipids) or metabolic p...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02231-7
更新日期：1996-06-01 00:00:00
abstract：:Thirty-six rats were injected IP with 2DG (0, 250, or 500 mg/kg) at 7-day intervals, once at light onset (7 a.m.) and once at dark onset (7 p.m.), and postinjection food intake was monitored for 24 hours. Five hundred mg/kg 2DG caused food intake to rise above control levels during the first 6 hours of daylight, regar...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90179-0
更新日期：1989-01-01 00:00:00
abstract：:Hypothyroidal rats produced by low iodine diet or propylthiouracyl (PTU) were less active in the open field and received fewer food reinforcements than controls in a lever press situation at both 22 degrees C and 1 degree C. The hypothyroid rats also pressed less when heat was the reinforcer. On the other hand, hypert...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90140-5
更新日期：1987-01-01 00:00:00
abstract：:Based upon his work with robots, Raibert proposed that a specific class of symmetry equations may be important to animals and humans during steady-state running. In a test of this hypothesis, Raibert found good agreement with his predictions. However, his test was limited to one cat at two speeds and a human at a sing...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90334-x
更新日期：1989-10-01 00:00:00
abstract：:Much of the inter-individual variation observed in animal behaviour is now attributed to the existence of behavioural phenotypes or animal personalities. Such phenotypes may be fundamental to fisheries and aquaculture, yet there have been few detailed studies of this phenomenon in exploited marine animals. We investig...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.03.010
更新日期：2012-06-25 00:00:00
abstract：:Given that approximately 25% of women in the United States continue to smoke cigarettes during pregnancy, it is important to know if exposure to nicotine during development alters the physiological response of the adult to the "stressors" of everyday life. Our current experiments were carried out to determine if prena...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00609-6
更新日期：2001-11-01 00:00:00
abstract：:The efficacy of two different unconditioned stimuli (US) in producing conditioned taste aversion (CTA) was tested in rats after bilateral ibotenic acid (IBO) lesions of the gustatory nucleus of thalamus (TTAx) and the medial and lateral parabrachial nuclei (mPBNx, lPBNx). An initial study determined an equivalent dose...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.12.008
更新日期：2006-03-30 00:00:00
abstract：:Due to previous work where we have demonstrated attenuated febrile responses post-lipopolysaccharide (LPS) in calorie restricted (CR) rodents we aimed to explore metabolic rate and behavioral thermoregulation in these CR animals post-LPS. Male Sprague-Dawley rats fed ad libitum (AL) or restricted to 50% (CR50%) of the...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.06.009
更新日期：2012-12-05 00:00:00
abstract：:The role of the area postrema in radiation-induced emesis and taste aversion learning and the relationship between these behaviors were studied in cats. The potential involvement of neural factors which might be independent of the area postrema was minimized by using low levels of ionizing radiation (100 rads at a dos...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90189-7
更新日期：1986-01-01 00:00:00
abstract：:The effects of gonadectomy and ovarian hormone treatment on food intake, body weight, and lordosis in male and female Mongolian gerbils were examined. In female gerbils, a significant decrease in food intake and body weight was observed after ovariectomy, with estradiol benzoate (1, 10, or 100 micrograms/day) increasi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90410-x
更新日期：1985-11-01 00:00:00
abstract：:Aggressive signaling is a key social behavior of male Siamese fighting fish (Betta splendens). Successfully establishing a territory and defending it from intruders has direct fitness effects, making Betta splendens a prime model for studies examining the biological underpinnings of aggressive behavior. Current resear...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.02.021
更新日期：2017-05-01 00:00:00
abstract：:Previous studies have shown that extensive damage to the medial prefrontal cortex (mPFC) of rats causes reversal learning deficits. The mPFC of rats, however, consists of several subareas that are different from each other in both cytoarchitecture and neural connectivity, suggesting a functional dissociation among the...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00216-9
更新日期：1998-11-15 00:00:00
abstract：:We tested the hypothesis whether daily food availability period would restore rhythmicity in individuals with disrupted circadian behavior with no effect on appetite regulation. Particularly, we investigated the effects of timed food availability on activity behavior, and Fos and neuropeptide Y expressions in Indian w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.04.017
更新日期：2016-07-01 00:00:00
abstract：:Leptin is a hormone secreted by adipocytes, which plays an important role in the control of food intake and metabolic processes. In the current study, a dose-dependent relationship was shown between a bolus intracerebroventricular rat recombinant leptin administration and reductions in food intake and body weight in S...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00243-1
更新日期：1999-01-01 00:00:00
abstract：:Body temperature (Tb) was monitored telemetrically in adult deer mice kept in an environmental chamber at low ambient temperature (Ta = 15 degrees C). Mice were challenged with various doses of 2-deoxy-D-glucose (2DG, a glycolysis inhibitor) or mercaptoacetate (MA, a fatty acid oxidation inhibitor) or a combination of...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(96)00495-7
更新日期：1997-04-01 00:00:00
abstract：:Ostracism causes social pain and is known to activate regions of the brain that are involved in the representation of physical pain. Previous research has observed that acetominophen (a common pain reliever) can reduce the pain of exclusion. The taste and consumption of glucose can also relieve physical pain, and the ...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2013.10.032
更新日期：2014-01-30 00:00:00
abstract：:Male hooded rats (350 to 450 g) were castrated and given subcutaneous implants of testosterone-filled or empty Silastic tubes. Four weeks later, half of the animals with testosterone implants were housed with an animal with an empty implant and left for 6 weeks. The other animals were adapted to a food-deprivation sch...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90285-0
更新日期：1989-04-01 00:00:00
abstract：:Winning competitions has been shown to lead to higher testosterone (T) relative to losing in men and males of other species. In Experiment 1, 38 women and 37 men provided a saliva sample, completed a novel computer-based vocabulary competition task at which they won or lost based on their own ability, provided feedbac...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.11.017
更新日期：2007-03-16 00:00:00
abstract：:Jumping is a simple exercise determined by several biomechanical and physiological factors. Measures of vertical jump height are common and easy to administer tests of lower limb muscle power that are carried out with several types of equipment. This study aimed to validate and address the usefulness of the combinatio...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113144
更新日期：2020-12-01 00:00:00
abstract：:Rats received total bilateral subdiaphragmatic vagotomy and, one month later, were fitted with chronic intravenous or intracerebroventricular cannulas. The vagotomized rats showed much reduced drinking compared with controls during intravenous infusion of angiotensin II. Their drinking to intracerebroventricularly adm...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(80)90068-2
更新日期：1980-06-01 00:00:00
abstract：:The effects of substantia nigra (SN) (pars compacta) stimulation on the rage reaction elicited by ventromedial hypothalamic nucleus (VMH) were investigated in the cat. The studied parameters of the rage reaction were: the current and the frequency threshold for the appearance of the hissing and the hissing latency. A ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90395-1
更新日期：1986-01-01 00:00:00
abstract：:As with mosquitoes, female tabanid flies search for mammalian hosts by visual and olfactory cues, because they require a blood meal before being able to produce and lay eggs. Polarotactic tabanid flies find striped or spotted patterns with intensity and/or polarisation modulation visually less attractive than homogene...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2013.06.013
更新日期：2013-07-02 00:00:00
abstract：:Vasopressin has been reported to be an endogenous antipyretic peptide. The present study assessed whether this peptide has similar effects on stress-induced hyperthermia. Infusion of 3 ng of vasopressin into the lateral ventricle prior to a 40-min restraint stress reduced significantly the hyperthermic response of rat...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：:Tonic immobility (TI) is considered to be a final stage in a sequence of defensive responses occurring in the prey/predator encounter. It is known that the basal midbrain of toads is involved in the organization of defensive behavior and analgesia. This study investigated the effect of electrolytic or neurotoxic lesio...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(00)00433-9
更新日期：2001-02-01 00:00:00
abstract：:Pigeons were exposed to fixed-time food schedules of 30, 120, and 480 sec with two reinforcer magnitudes at each. Attack behavior against a rear-projected conspecific image was assessed at each interfood/reinforcer magnitude combination. For seven of eight subjects, attack rate was related to interfood interval by an ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90140-y
更新日期：1990-02-01 00:00:00
