Abstract：
:Previous studies have shown that extensive damage to the medial prefrontal cortex (mPFC) of rats causes reversal learning deficits. The mPFC of rats, however, consists of several subareas that are different from each other in both cytoarchitecture and neural connectivity, suggesting a functional dissociation among the mPFC subareas. In the present study, selective lesions of the mPFC of rats were made with a specially designed microknife whose intracranial placement could be controlled stereotaxically. Restricted lesions were made to each of the 3 parts of the mPFC: the anterior cingulate area (AC) (including the medial precentral area, PrCm), the prelimbic area (PL), and the infralimbic area (IL). One week after surgery, rats were trained in an aversively motivated visual discrimination task in a novel rotating T-maze. After reaching the acquisition criterion, rats were trained in a reversal task in the same maze. No difference was found in acquisition between control and mPFC lesioned rats. However, lesions of either the PL or the IL produced a marked deficit in the reversal task. This behavioral deficit was not found in rats with lesions of the AC. The results indicate that the mPFC of rats is not essential for discrimination learning, but that each of the 2 ventral subareas of the mPFC, PL, and IL, plays a critical role in reversal learning.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Li L,Shao Jdoi
10.1016/s0031-9384(98)00216-9subject
Has Abstractpub_date
1998-11-15 00:00:00pages
371-9issue
2eissn
0031-9384issn
1873-507Xpii
S0031-9384(98)00216-9journal_volume
65pub_type
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pub_type： 杂志文章,评审
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journal_title：Physiology & behavior
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更新日期：1983-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1994-07-01 00:00:00
