Abstract:
:Oxytocin treatment in rats induces long-lasting antistress and growth promoting effects. This study investigated whether prolyl-leucyl-glycinamide (PLG) (the c-terminal tripeptide of oxytocin) or tocinoic acid (the ring structure of oxytocin) could induce some of these effects in male rats. For this purpose, PLG (2 or 10 mg/kg, s.c.) or tocinoic acid (1 mg/kg, s.c.) was administered to rats once a day for 3 or 5 days. Blood pressure, heart rate, spontaneous motor activity, nociceptive thresholds, and the survival of ischaemic musculocutaneous flaps were measured. In addition, endogenous oxytocin levels and plasma levels of some hormones known to be influenced by oxytocin were determined. PLG (2 mg/kg, s.c., but not 10 mg/kg, s.c.) decreased diastolic blood pressure (p<0.05) and locomotor activity (p<0.05). PLG (10 mg/kg, s.c.) decreased gastrin (p<0.05) and endogenous oxytocin levels in plasma (p<0.01). Tocinoic acid decreased locomotor activity (p<0.05), but did not affect any of the other parameters measured. In conclusion, this study showed that both PLG and tocinoic acid decrease locomotor activity. In addition, PLG also induced some other effects similar to those induced by oxytocin treatment but when administered in high doses it decreased oxytocin levels.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Petersson M,Uvnäs-Moberg Kdoi
10.1016/j.physbeh.2004.08.034subject
Has Abstractpub_date
2004-12-15 00:00:00pages
475-81issue
3eissn
0031-9384issn
1873-507Xpii
S0031-9384(04)00386-5journal_volume
83pub_type
杂志文章abstract::Hyp mice are a model for X-linked hypophosphatemia, the most common form of vitamin D-resistant rickets. Previous reports indicate alterations in the nervous system of these mice. The present study examined rearing and step climbing behavior in Hyp mice in the staircase test. We found that male Hyp mice have large red...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90195-8
更新日期:1987-01-01 00:00:00
abstract::Noise exposure during the critical period of postnatal development in rats results in anomalous processing of acoustic stimuli in the adult auditory system. In the present study, the behavioral consequences of an acute acoustic trauma in the critical period are assessed in adult rats using the acoustic startle reflex ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2010.12.010
更新日期:2011-03-28 00:00:00
abstract::The synthetic octapeptide of cholecystokinin (CCK-8) was infused at the rate of 67 ng/kg-minute into the jugular vein, carotid artery, portal vein, gastric branch of the splenic artery, and aortic artery both craniad and caudad to the origins of the cranial mesenteric and coeliac arteries of 39 young female pigs. Jugu...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(83)80005-5
更新日期:1983-11-01 00:00:00
abstract::It is known from previous research that physical exercise prevents long-term memory deficits induced by maternal deprivation in rats. But we could not assume similar effects of physical exercise on short-term memory, as short- and long-term memories are known to result from some different memory consolidation processe...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.09.019
更新日期:2015-12-01 00:00:00
abstract::An operant chamber has been developed for studying lever-press conditioning in the green crab Carcinus maenas. In one series of experiments, animals were presented with a single bar and were reinforced with food for every bar press. Performance increased over time and high rates of responding were observed after 2 day...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90311-q
更新日期:1990-08-01 00:00:00
abstract:OBJECTIVE:Epilepsy is the most common neurological chronic condition worldwide, affecting about 2% of world population. Temporal lobe epilepsy (TLE) reaches 40% of all cases of this condition, and it is highly refractory to pharmacological treatment. Physical activity has been suggested as complementary therapy for epi...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2016.12.040
更新日期:2017-03-15 00:00:00
abstract::The aim of this study was to evaluate the effects of intraspecific social exposure (socialization vs rest) and habituation factors on the levels of urinary serotonin and cortisol [corrected respectively for creatinine to give the serotonin-creatinine ratio (5-HT/Cr) and cortisol-creatinine ratio (C/Cr)] and how they f...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.03.016
更新日期:2019-07-01 00:00:00
abstract::Sugar-sweetened beverage (SSB) taxation has emerged as a priority policy for promoting health and funding investments in communities most affected by diet-related disease. There are now 8 U.S. jurisdictions and over 40 countries that have implemented SSB taxes. Evaluations show that these policies reduce SSB consumpti...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113105
更新日期:2020-10-15 00:00:00
abstract::Certain popular models of the regulation of food intake predict a positive correlation between the size of a meal and the preceding and/or following intermeal interval. However, the reported strength of these prandial correlations has varied widely in the literature. To determine what factors may influence the strengt...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(99)00086-4
更新日期:1999-09-01 00:00:00
abstract::Four groups of pigeons each were trained to perform four visual-discrimination tasks of varying difficulty. Two groups received the training binocularly and the other two monocularly. Two types of stimulus displays were used. In one display the two pecking keys were mounted in a horizontal arrangement, whereas, in the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90204-x
更新日期:1984-05-01 00:00:00
abstract::Single and multiple unit activity was recorded from the amygdaloid nuclei in awake unanesthestized rabbits during classical conditioning of the nictitating membrane (NM) response. Over half o the unit recordings from the amygdaloid complex demonstrated changes in firing rate following the presentation of the tone cond...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90306-8
更新日期:1984-04-01 00:00:00
abstract::Six goldfish, Carassius auratus, weighing 2.5 to 4 g were placed individually in an aquarium with two communicating chambers. One chamber was thermostatted at 34 degrees C, the other at 37 degrees C. In control Session a, without external intervention, fish selected the cooler chamber most of the time and stayed only ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00444-7
更新日期:1998-02-01 00:00:00
abstract::The startle behaviour of the fetus (both spontaneous and elicited) was examined in fetuses of mothers who drank alcohol and mothers who did not. Fetuses exposed to alcohol showed a higher frequency of spontaneous startles and were less likely to exhibit a normal startle in response to a vibroacoustic stimulus. These d...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章
doi:10.1016/s0031-9384(02)00804-1
更新日期:2002-08-01 00:00:00
abstract::Electrophysiological and behavioral studies of vigilance states were performed on adult specimens of the parakeet Melopsittacus undulatus. Four states of vigilance were identified: Wakefulness, drownsiness, slow wave sleep and paradoxical sleep. During wakefulness, a low voltage fast EEG pattern was observed. This pat...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(89)90038-3
更新日期:1989-11-01 00:00:00
abstract::The present studies sought to determine whether prenatal cocaine administration (15 mg/kg b.i.d. between gestational ages 1-20) had enduring effects on emotional behavior of rats. Rats prenatally treated with cocaine interacted less with other rats in the social interaction test of anxiety at both 30 and 120 days of a...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(00)00245-6
更新日期:2000-07-01 00:00:00
abstract::The present article analyzed the dramatic increase in alcohol ingestion that is known to occur in laboratory rats subjected to food restriction. In the first experiment, we wished to know when during the day food restricted animals consume the "extra" alcohol ration. Determinations of ethanol drinking at 3-h intervals...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(99)00078-5
更新日期:1999-09-01 00:00:00
abstract::l-phenylalanine (Phe) has been shown to elicit release of the gut hormone cholecystokinin (CCK) and reduce energy intake. Furthermore, studies in some animal models demonstrate potentiation of CCK-induced satiety by estradiol (E(2)). As E(2) is elevated in the follicular phase, we expected greater satiety effects than...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2007.11.051
更新日期:2008-03-18 00:00:00
abstract::Cage stocking density can be manipulated by changing in cage size and group size in the cage. The effects of these two factors were investigated in three developmental stages in male rats: juvenile, post-pubertal, and adult. An open-field test was conducted to measure exploratory behavior which was influenced by level...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2005.01.008
更新日期:2005-03-16 00:00:00
abstract::In mammals, body mass at birth is an important predictor of early postnatal growth and survival. Within litters, heavier young are more successful in competing for limited resources and show higher rates of growth and survival than their lighter sibs. In the present study, we investigated the contribution of two aspec...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.10.028
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Time-restricted feeding (TRF), a key component of intermittent fasting regimens, has gained considerable attention in recent years due to reversing obesity and insulin resistance. To the best of our knowledge, here, we reported for the first time the underlying mechanistic therapeutic efficacy of TRF against...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2021.113313
更新日期:2021-03-15 00:00:00
abstract::In earlier work, we found that following lipopolysaccharide (LPS) injection at an ambient temperature (Ta) of 23 degrees C, old rats developed blunted fevers compared with those of young rats. However, the old rats did become febrile if placed in a thermally graded alleyway: they spent more time in the warm end of the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(03)00046-5
更新日期:2003-04-01 00:00:00
abstract::Roux-en-Y gastric bypass (RYGB) surgery might modify the gut microbiota composition differently in the three distinct anatomical sections of the small intestine compared to sham surgery. We showed that RYGB induced changes in the microbiota of the alimentary limb and the common channel resembling those seen after preb...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2013.06.008
更新日期:2013-07-02 00:00:00
abstract::The purpose of the present study was a description of hormonal profiles in female prairie voles (Microtus ochrogaster) in estrus that was induced by male exposure versus postpartum estrus. Hormonal profiles are reported in sexually naive females and in sexually experienced females, as a function of varying amounts of ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(89)90195-9
更新日期:1989-12-01 00:00:00
abstract::Reward-related stimuli come to acquire incentive salience through Pavlovian learning and become capable of controlling reward-oriented behaviors. Here, we examined individual differences in anticipatory activity elicited by reward-related cues as indicative of how animals attribute incentive salience to otherwise neut...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.05.012
更新日期:2015-10-01 00:00:00
abstract::Sedentary, adult rats of both sexes fed Purina chow and a 32% sucrose solution overate, gained excess weight and had higher Lee Indexes of obesity than control animals fed only Purina chow. The magnitude of these effects was similar in the males and females. Animals of both sexes fed the sucrose diet showed a slower r...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90012-9
更新日期:1982-08-01 00:00:00
abstract::Both major depression and depressive symptoms are associated with a high rate of nicotine dependence, and a history of major depression has an adverse impact on smoking cessation. The main objective of this study was to investigate whether continuous ingestion of nicotine affects indices of depressive behavior in the ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(99)00091-8
更新日期:1999-10-01 00:00:00
abstract::Male rats, fitted with indwelling gastric fistulas, were tested with either a closed fistula (normal drinking) or an open fistula (sham drinking) following either intracellular dehydration (with NaCl), extracellular dehydration (with PEG), or the combination of the two stimuli. In normal drinking tests, the combined s...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90068-f
更新日期:1990-04-01 00:00:00
abstract::We examined the effects of 30 min of cycling exercise at a moderate intensity of 50% peak oxygen uptake, compared to 30 min of rest, on changes in emotional responses to pictorial foreground stimuli that reliably elicit unpleasant, neutral, and pleasant affect. Emotional responses were measured by self-reports of vale...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.10.001
更新日期:2007-02-28 00:00:00
abstract::Compared to male secondary sexual traits, the effect of testosterone (T) on female ornaments is understudied. In particular, it is unclear whether females experience different costs of T elevation than do males and how this affects the relationship between T and ornamentation in the two sexes. I experimentally and cor...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.04.003
更新日期:2006-07-30 00:00:00
abstract::We examined the time course and sex differences of the glucocorticoid response to forced, moderate-intensity treadmill exercise in outbred laboratory house mice. Mice (n = 64 total) were divided into eight groups, each of four males and four females, which were run on a motorized treadmill at 1.0 km/h for either 0, 2,...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00441-1
更新日期:1998-01-01 00:00:00