Abstract：
:Acetyl-l-carnitine (ALC), a natural component of several biological systems, has been found to modify spontaneous and evoked electrocortical activity in young rats and to improve learning ability in old ones. In clinical application it also improves mood and attention in elderly patients. The present study was aimed at ascertaining the effect of a chronic treatment with ALC added to drinking water on two discrimination models in aged rats. In the first model, simple discrimination learning was tested and was found to be significantly improved by treatment. The second model consisted of a differential reinforcement of low rate of responding. The animals receiving treatment performed significantly better as shown by a lower number of nonrewarded responses. Because impaired learning and memory are related to alterations in hippocampal function, these data indicate that ALC is capable of antagonizing the natural age-dependent deterioration process in the hippocampal structure.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Ghirardi O,Milano S,Ramacci MT,Angelucci Ldoi
10.1016/0031-9384(88)90060-1subject
Has Abstractpub_date
1988-01-01 00:00:00pages
769-73issue
6eissn
0031-9384issn
1873-507Xpii
0031-9384(88)90060-1journal_volume
44pub_type
杂志文章abstract：:Adequate energy intake is vital for the survival of humans and is regulated by complex homeostatic and hedonic mechanisms. Supported by functional MRI (fMRI) studies that consistently demonstrate differences in brain response as a function of weight status during exposure to appetizing food stimuli, it has been posite...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2014.04.025
更新日期：2014-09-01 00:00:00
abstract：:The effects of chronic social stress on behavioral sensitization to cocaine were investigated in the Syrian hamster. Adolescent animals received either 15 mg/kg i.p. of cocaine or saline twice per day for 7 consecutive days. Two weeks following the last injection (young adulthood), they were given a challenge dose of ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00727-8
更新日期：2002-08-01 00:00:00
abstract：:Sea bass, a fish species characterized by its dualistic feeding pattern, was investigated to study the synchronizing effect of light and food on the demand-feeding rhythm. Nocturnal and diurnal sea bass, both in groups and individually, were exposed to restricted-feeding (RF) and light-dark (LD) cycles of different pe...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00116-z
更新日期：1995-10-01 00:00:00
abstract：:Rats maintained on limited-access daily feeding schedules develop food-anticipatory activity rhythms which coexist with the photic circadian activity rhythm. These food anticipatory rhythms appear to depend upon a food-entrainable circadian oscillator which is separate and distinct from the light-entrainable circadian...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90064-7
更新日期：1984-01-01 00:00:00
abstract：:Sexually experienced male rats were injected IP with 0, 0.3, 1.5, 3.0, or 6.0 mg/kg cadmium chloride. The highest dose was fatal within 48 h of injection. A dose-related deficit in erectile function was observed in ex copula tests 48 h after injection. Copulatory dysfunction was evident in mating tests 72 h after inje...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90332-8
更新日期：1994-11-01 00:00:00
abstract：:Medroxyprogesterone acetate (MPA), a synthetic progestin with androgen-depleting activity, is used to treat the deviant sexual behavior of men. To investigate the effects of MPA in another anthropoid primate, 16 oppositely-sexed pairs of cynomolgus monkeys were observed in one-hour behavior tests during 15 successive ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90275-2
更新日期：1988-01-01 00:00:00
abstract：:A simple device constructed from inexpensive components enables spike activity to be integrated and displayed in a convenient scale (spikes/sec) on a pen recorder. An input voltage threshold detection circuit is employed to eliminate any random baseline noise from being integrated. A pulse output is provided to drive ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(75)90151-1
更新日期：1975-01-01 00:00:00
abstract：:High performance liquid chromatography (HPLC) with electrochemical detection proves to be a reliable method for determination of plasma catecholamines (CA) to assess the possible role of the sympathetic nervous system (SNS) in essential hypertension (EH). The present investigation in a group of 15 normotensive (N) and...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90302-5
更新日期：1991-04-01 00:00:00
abstract：:Postcopulatory genital autogrooming was studied in rats following desensitization of the glans penis due to topical application of an anesthetic ointment or to surgical transection of the dorsal penile nerve. These treatments sharply reduced the number of mounts resulting in intromission, but genital autogrooming was ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90228-x
更新日期：1989-05-01 00:00:00
abstract：:Lactic acid in arterial blood, systolic and diastolic blood pressures, and heart rates of baboons were examined for three naive subjects, and for five experimental subjects during baseline conditions and during training to elevate diastolic blood pressure through operant conditioning methodology. Lactic acid and cardi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90235-9
更新日期：1982-10-01 00:00:00
abstract：:Using a combination of injection cannula and recording electrode, the effect of 1 microliter of 3 mM verapamil upon the multiunit responses evoked in the peripeduncular nucleus (PPN) by electric stimuli applied to the pudendal nerves in urethane anesthetized proestrous female rats was studied in 9 experiments. It was ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90170-9
更新日期：1988-01-01 00:00:00
abstract：:Isolation rearing from weaning has been reported to enhance excitatory conditioning. The present study employed a conditioned inhibition procedure to examine whether this result was attributable to locomotor hyperactivity. Rats were raised from 21 days old in isolation or in groups of five. In Phase 1, presentation of...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00207-8
更新日期：1998-12-01 00:00:00
abstract：:Sleep/wake expression in mice varies predictably with circadian phase. Such circadian rhythms are known to depend on intact suprachiasmatic nuclei (SCN) in the hypothalamus, but the mechanism by which SCN activity modulates sleep/wake expression is unknown. This paper examines the possibility that circadian patterns o...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90375-7
更新日期：1988-01-01 00:00:00
abstract：:When animals are reared for conservational releases it is paramount to avoid reducing genetic and phenotypic variation over time. This requires an understanding of how diverging behavioural and physiological traits affect performance both in captivity and after release. In Atlantic salmon, emergence time from the spaw...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.03.028
更新日期：2017-06-01 00:00:00
abstract：:We determined the serum levels of calcitonin (CT), calcium (Ca), and thyroxine (Ti) in lean (?/+) and fatty (fa/fa) male Zucker rats 10 weeks and 10-12 months of age. The most dramatic finding was a high level of serum CT (3.24 +/- 1.18 ng/ml) in young fatties whereas sera from young leans were all below the limit of ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90099-9
更新日期：1983-07-01 00:00:00
abstract：:The purpose of the present study was to examine the impact of nutritional supplementation with essential omega 3 and 6 fatty acids on CA1 neuronal death and recovery of functional impairments following global ischemia. Groups of Wistar male rats were randomly assigned to four experimental conditions determined by the ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.07.020
更新日期：2008-10-20 00:00:00
abstract：:Sexually dimorphic pheromone pathways have been used successfully to study insect olfactory coding. As one of the few mammalian species with an identified sex pheromone, the domestic pig (Sus scrofa) may be an ideal vertebrate species in which to examine sex differences in olfactory processing of a specific stimulus. ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00225-t
更新日期：1995-02-01 00:00:00
abstract：:The zebrafish has become increasingly utilized in behavioral neuroscience, psychopharmacology, and behavior genetics research. However, little attention has been paid to the potential effects of environmental conditions fish are exposed to before and during behavioral testing. One such important factor is temperature,...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113169
更新日期：2020-12-01 00:00:00
abstract：:The aim of the study was to investigate the illuminance selected in the morning by subjects whose face was cooled and whose tympanic temperature has been lowered by 0.15-0.25 degrees C. The hypothesis tested was that a difference between the actual core temperature and its set point (load error) will influence the pre...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/j.physbeh.2003.12.015
更新日期：2004-03-01 00:00:00
abstract：:Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from intestinal L-cells in response to food entering into the gastrointestinal tract. GLP-1-based pharmaceuticals improve blood glucose regulation and reduce feeding. Specific macronutrients, when ingested, may trigger GLP-1 secretion and enhance the effe...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.04.017
更新日期：2017-08-01 00:00:00
abstract：:is well established that, on the anterior tongue, thresholds for chemical tastants are inversely related to the number of fungiform papillae. However, it is not known whether this is the case for thresholds to electrical currents presented to the lingual surface. In this study, electrical thresholds for 16 subjects we...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00672-8
更新日期：2002-04-15 00:00:00
abstract：:Pine voles (Microtus pinetorum) were given sipper tubes containing saccharin solution, and after drinking, were injected with 0.15 M LiCl. Subsequently, two-sipper tests were given to assure the presence of conditioned flavor avoidance (CFA), and then animals were presented with saccharin in carboxymethyl-cellulose on...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90269-0
更新日期：1985-12-01 00:00:00
abstract：:Two behavioral experiments were performed to determine if the housing conditions modify taste preferences, body weight gain, food and fluid intake, and alimentary diurnal pattern in adult male rats. In Experiment 1, a two-bottle 24-h preference test (salt, sweet, sour, bitter solutions versus deionized water) was perf...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90374-b
更新日期：1992-11-01 00:00:00
abstract：:The effects of ethanol on blood pH, PCO2, and PO2 were measured in LS and SS mice in an attempt to ascertain whether these lines of mice, which differ in CNS sensitivity to the behavioral effects of ethanol, also differ in sensitivity to physiological effects of this drug. Long-sleep (LS) female mice were injected int...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90208-6
更新日期：1982-05-01 00:00:00
abstract：:Tempting environmental food cues and metabolic signals are important factors in appetite regulation. Food intake reduces liking of food cues that are congruent to the food eaten (sensory-specific satiety). With this study we aimed to assess effects of sensory-specific satiety on neural processing (perceptual and evalu...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.08.020
更新日期：2018-11-01 00:00:00
abstract：:Cautery disbudding of goat kids causes thermal burns and tissue destruction, which results in acute and post-operative pain and negatively affects animal welfare. The objectives of this study were to evaluate acute cortisol concentrations and behavioral responses associated with (1) injecting a lidocaine ring block pr...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.112942
更新日期：2020-08-01 00:00:00
abstract：:The effects of deafferentation of the vomeronasal, olfactory or both systems of male mice on ultrasonic vocalizations in response to a male or female stimulus were analyzed. Regardless of the technique used, disruption of the vomeronasal system led to consistent reductions in ultrasonic vocalizations. Each animal rece...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90097-x
更新日期：1982-01-01 00:00:00
abstract：:Rats received total bilateral subdiaphragmatic vagotomy and, one month later, were fitted with chronic intravenous or intracerebroventricular cannulas. The vagotomized rats showed much reduced drinking compared with controls during intravenous infusion of angiotensin II. Their drinking to intracerebroventricularly adm...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(80)90068-2
更新日期：1980-06-01 00:00:00
abstract：BACKGROUND:Studies evaluating the efficacy of anti-inflammatory treatment strategies for major depressive disorder (MDD) commonly include participants who do not demonstrate elevated concentrations of baseline inflammatory mediators, or simply fail to assess baseline inflammation. This may result in an underestimation ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.05.006
更新日期：2019-08-01 00:00:00
abstract：:Young, specific-pathogen-free cats were fed purified diets containing different sources of fat. Food intake was depressed and cats lost weight when the diet contained either hydrogenated coconut oil (HCO) or medium-chain triglycerides (MCT). With an MCT preparation enriched in 8:0 (MCT8), cats would not eat after firs...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90311-7
更新日期：1985-09-01 00:00:00
