Abstract：
:The purpose of the present study was to examine the impact of nutritional supplementation with essential omega 3 and 6 fatty acids on CA1 neuronal death and recovery of functional impairments following global ischemia. Groups of Wistar male rats were randomly assigned to four experimental conditions determined by the consumed diet and surgical condition. Rats either received a standard diet (SD; Purina 5012) or a 15% PUFA supplemented diet (FO+CO) prepared by adding 11.5% (w/w) fish oil from menhaden fish and 3.5% corn oil to standard rat chow. Diet conditions were initiated in 30 day old rats and maintained for an 18-week period (pre- and post-surgery). Sham or 8-min global ischemic surgeries occurred during the 13th feeding week and behavioral testing took place following reperfusion for an additional 4 weeks, after which all rats were euthanized. Our findings revealed significant loss of pyramidal CA1 neurons 31 days post ischemia in ischemic as compared to sham-operated rats but no difference between ischemic animals fed the SD or PUFA supplemented diets. In the radial arm maze, SD ischemic rats took longer time to complete the task and made significantly more working memory errors than PUFA ischemic and sham-operated animals. Independent of the diet, ischemic animals appeared less anxious in the elevated plus maze, spending considerably more time in the open arms as compared to sham-operated rats. Taken together, these results suggest that fish oil supplemented diet exerts beneficial effect on ischemia-induced spatial memory deficits despite protective effects on CA1 hippocampal neurons.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Plamondon H,Roberge MCdoi
10.1016/j.physbeh.2008.07.020subject
Has Abstractpub_date
2008-10-20 00:00:00pages
492-500issue
3eissn
0031-9384issn
1873-507Xpii
S0031-9384(08)00229-1journal_volume
95pub_type
杂志文章abstract：:Norway rat dams were placed in an ambient temperature of 4 degrees C, 22 degrees C, or 28 degrees C. Body temperatures were recorded over a two hour period on three days; each female was observed on Day 4 and Day 10 of lactation and three days after lactation was stopped. Body temperatures were initially higher during...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90261-5
更新日期：1983-06-01 00:00:00
abstract：:Reaction times and perceived intensities for NaCl solutions were measured in sixteen human adults. Stimulus delivery was by means of a circular piece of solution-soaked filter paper held with forceps. The reaction time (T) decreased and the perceived intensity (S) increased with increasing the concentration (C) of NaC...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90369-9
更新日期：1982-07-01 00:00:00
abstract：:Intranasal oxytocin produces anorectic effects on snack intake in men when tested in the absence of deprivation-induced hunger, but its effects on food intake in women without eating disorders have not been reported. Oxytocin may reduce food intake by reducing stress eating, since it inhibits ACTH release. The present...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2019.112704
更新日期：2019-12-01 00:00:00
abstract：:To investigate the possible involvement of leptin signaling in lipopolysaccharide (LPS) anorexia, we compared the anorectic effect of LPS in genetically obese (fa/fa) Zucker rats and in their lean (Fa/?) counterparts. The effects of interleukin-1beta (IL-1beta) and muramyl dipeptide (MDP) were also tested. LPS [100 mi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.11.003
更新日期：2005-01-31 00:00:00
abstract：:We have previously reported that the opioid receptor blocker, naloxone, is less effective in reducing palatable food intake in offspring exposed to a maternal cafeteria diet during the perinatal period, implicating a desensitization of the central opioid pathway in the programming of food preferences. The present stud...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.04.007
更新日期：2014-06-22 00:00:00
abstract：:As the best-studied form of vertebrate synaptic plasticity, NMDA-receptor dependent long-term potentiation (NMDAR-LTP) has long been considered a leading candidate for a cellular locus for some aspects of learning and memory. However, assigning a specific role for this form of plasticity in learning and memory has pro...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/s0031-9384(01)00514-5
更新日期：2001-08-01 00:00:00
abstract：:The role of the area postrema in radiation-induced emesis and taste aversion learning and the relationship between these behaviors were studied in cats. The potential involvement of neural factors which might be independent of the area postrema was minimized by using low levels of ionizing radiation (100 rads at a dos...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90189-7
更新日期：1986-01-01 00:00:00
abstract：:The effect of epileptogenic lesion of amygdala on spatial working memory was examined in rats after unilateral (U, n = 9) or bilateral (B, n = 8) injection of 1 or 0.5 mu of 0.2% kainate into the amygdaloid complex. Another group of unilaterally lesioned rats (T, n = 9) received 8 days after kainate injection grafts o...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90124-8
更新日期：1989-02-01 00:00:00
abstract：:The development of liking for flavours through conditioning has so far been widely demonstrated in the laboratory. The impact of conditioning in the real world however is yet to be reported. This study investigated the development of liking for flavours through conditioning in the real world as part of everyday life. ...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/j.physbeh.2005.11.017
更新日期：2006-03-30 00:00:00
abstract：:Retrochiasmatic frontolateral knife cuts (FLC) or sham operations (Sham) were performed with a Halasz-type knife. All animals were primed with estrogen plus 0.5 mg progesterone (P) and tested for lordosis both before and after surgery. Two weeks after the last test they received estradiol (E2) in Silastic capsules and...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90008-7
更新日期：1982-08-01 00:00:00
abstract：:Although female aggression is found in many species and in a variety of contexts, little is known about its physiological bases. To compare neuroendocrine responses to aggression in females and males, we staged aggressive interactions between free-living territorial mountain spiny lizards and same-sex intruders and me...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(00)00345-0
更新日期：2000-11-01 00:00:00
abstract：:Previous researchers have assumed that malaise-inducing drugs condition aversions to tastes more readily than to textural stimuli. The present report shows that rats given a single injection of lithium chloride after they have sampled a viscous fluid, subsequently showed greater avoidance of that fluid than did contro...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90373-a
更新日期：1992-11-01 00:00:00
abstract：:Young pigs, which are useful experimental animals for biomedical research, were prepared with lateral intracerebroventricular (ICV) cannulae and housed individually in cages fitted with operant panels, with food and water ad lib. ICV injection of 200 micrograms of dynorphin A 1-17 or 1-13 resulted in a significant mea...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90233-t
更新日期：1990-12-01 00:00:00
abstract：:The environmental factors that arrest breeding in prairie voles during the middle of the breeding season are unknown. The role of water availability on reproductive function was examined by limiting water intake to 50% of ad lib water consumption for 10 weeks. At autopsy, testicular, epididymal and seminal vesicle mas...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90047-4
更新日期：1989-11-01 00:00:00
abstract：:The source of innervation to the brood patch in turkey hens was determined by recording the electrophysiological activity of cutaneous nerves while manually stimulating various regions of the skin. The entire area of the brood patch was innervated by eight nerves, arising from thoracic vertebra 3 to synsacrothoracic v...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90067-x
更新日期：1991-08-01 00:00:00
abstract：:To characterize learning/memory profiles for the first time in the genetically heterogeneous NIH-HS rat stock, and to examine whether these are associated with anxiety, we evaluated NIH-HS rats for spatial learning/memory in the Morris water maze (MWM) and in the following anxiety/fear tests: the elevated zero-maze (Z...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.03.003
更新日期：2015-05-15 00:00:00
abstract：:The existence of the retino-hypothalamic pathway suggests that light stimulation may influence the activity of the autonomic outflows. Efferent activities of the pancreatic, hepatic, and gastric branches of the vagus nerve and those of pancreatic, hepatic, splenic, adrenal, and renal branch of the splanchnic nerve wer...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90249-f
更新日期：1993-09-01 00:00:00
abstract：:KINSEY, S. G., BAILEY, M. T., SHERIDAN, J. F., PADGETT, D. A. The inflammatory response to social defeat is increased in older mice. PHYSIOL BEHAV 91(0) 000-000, 2007. Previous research indicates that repeated social defeat of mice causes increased lymphocyte trafficking to the spleen, elevated proinflammatory cytokin...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.11.003
更新日期：2008-02-27 00:00:00
abstract：:To investigate brain substrates of spatial memory, neuronal expression of c-Fos protein was studied. Two groups of rats were trained in two spatial memory tasks in the Morris water maze, where the rats have to apply a reference memory rule or a working memory rule. In addition to the experimental groups, two control g...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(03)00060-x
更新日期：2003-04-01 00:00:00
abstract：:Schisantherin A (STA) is a main bioactive lignan isolated from Schisandra chinensis (Turcz.) Baill., which has been widely used as a tonic in traditional Chinese medicine for many years. Lots of studies have reported that STA exhibited anti-inflammatory and antioxidant effects. This paper was designed to investigate t...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.04.046
更新日期：2014-06-10 00:00:00
abstract：:Amino acid deficiency was modeled by feeding rats a diet deficient in the essential L-amino acid, L-lysine (L-lys). There is a rapid anorectic response to such a diet, and a strong preference for L-lys develops during the deficiency. While the brain appears to trigger this preference, the peripheral pathways that info...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00426-7
更新日期：2001-04-01 00:00:00
abstract：:Subjects consumed soup (beef consomme) preloads of a fixed size containing different concentrations of monosodium L-glutamate (MSG). Effects on appetite following these preloads, and when no soup was consumed, were assessed in 3 studies. The soups supplemented with MSG were rated as more "pleasant," more "savoury" and...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90230-2
更新日期：1990-12-01 00:00:00
abstract：:Bulbectomy has been previously shown to produce the specific antidepressant-sensitive syndrome in C57Bl/6j, but not DBA/2j mice. The present study examined the effect of the depression on voluntary alcohol consumption. Alcohol consumption and alcohol preference (% of alcohol solution in total liquid) in a free-choice,...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90293-3
更新日期：1994-09-01 00:00:00
abstract：:A double sampling procedure, developed originally for investigation of liquid phase gastric emptying in humans, is adapted for use in the rat. The double sampling technique permits repeated measurement of gastric volume, allowing a determination of a time course of emptying in a single experimental session. Further, t...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90226-5
更新日期：1987-01-01 00:00:00
abstract：:Taste expectations can influence taste evaluations. It is not known, however, whether the environmental cues that influence taste expectations--such as suggestible names and brand labels--can have a referred impact on the intake volume of companion foods. Adult diners who ordered a prix-fixe restaurant meal were given...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.12.010
更新日期：2007-04-23 00:00:00
abstract：:The subfornical organ (SFO), as one of the sensory circumventricular organs (CVOs), is among the only central nervous system structures which interfaces directly with circulating substances that do not cross the blood brain barrier. Here we describe a growing literature showing that circulating indicators of cardiovas...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2013.02.012
更新日期：2013-09-10 00:00:00
abstract：:Gross and subgross anatomical observations of the penis pointed to a mechanical arrangement whereby contraction of the bulbocavernosus (BC) muscles would enhance erections of the glans penis and contraction of the ischiocavernosus (IC) muscles would enhance or produce penis flips. These functions for the muscles were ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90277-9
更新日期：1983-12-01 00:00:00
abstract：:Many lateral hypothalamic electrodes that support self-stimulation also elicit feeding. Refractory period and conduction velocity estimates for the axons supporting these behaviors appear identical, suggesting that these behaviors may be elicited by stimulation of a common directly activated substrate. However, it is ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90007-q
更新日期：1990-05-01 00:00:00
abstract：:The sham feeding preparation was used to determine whether systemic estradiol administration inhibits the intake of 0.8 M sucrose of ovariectomized rats by decreasing the potency of pregastric controls of ingestion. During real feeding, significant reductions in the sucrose intake of estradiol-treated rats appeared wi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00271-6
更新日期：1995-01-01 00:00:00
abstract：:Taste sensitivity and responsivity, two-tastant and taste-mixture discrimination performance, and taste preferences were examined prior to and after the selective desalivation of 48 male Long-Evans rats. Altered preference behavior was observed in rats after removal of the major salivary glands, as well as after remov...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90200-n
更新日期：1990-11-01 00:00:00
