Abstract：
:As the best-studied form of vertebrate synaptic plasticity, NMDA-receptor dependent long-term potentiation (NMDAR-LTP) has long been considered a leading candidate for a cellular locus for some aspects of learning and memory. However, assigning a specific role for this form of plasticity in learning and memory has proven surprisingly difficult. Two issues have contributed to this difficulty. First, a large number of molecules have been shown to in some way mediate or modulate not only NMDAR-LTP but also many forms of plasticity. Indeed, it is increasingly clear that multiple induction and maintenance mechanisms for plasticity exist, often at the same synapse. Second, linking cellular events to behavioral function has been hindered by a lack of sufficiently precise tools. In this review, we will discuss some of the proposed mechanisms of induction and maintenance of changes in synaptic efficacy and their regulation in the context of an attempt to understand their roles in animal behavior. Further, we will discuss recently developed genetic techniques, specifically, inducible transgenic models, which now allow more precise manipulations in the study of the roles plasticity plays in learning and memory.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Winder DG,Schramm NLdoi
10.1016/s0031-9384(01)00514-5subject
Has Abstractpub_date
2001-08-01 00:00:00pages
763-80issue
5eissn
0031-9384issn
1873-507Xpii
S0031-9384(01)00514-5journal_volume
73pub_type
杂志文章,评审abstract：:The present experiment investigated the effects of exposure to inescapable shocks (IS) on subsequent behavior in an elevated plus-maze and on shuttlebox-escape performance in male and female rats. In the elevated plus-maze, exposure to IS resulted in suppression of "total number of arm entries" and "rearings" in males...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90302-k
更新日期：1990-10-01 00:00:00
abstract：:Psychological stressors are known to increase core body temperature (T(c)) in laboratory animals. Such single stress-induced hyperthermic responses are typically monophasic, as T(c) returns to baseline within several hours. However, studies on the effects of repeated psychological stress on T(c) are limited. Therefore...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.04.027
更新日期：2010-08-04 00:00:00
abstract：:The medial preoptic area of the anterior hypothalamus (MPOA/AH) and the dorsolateral tegmentum (DLT) play an important role in the control of sexual behavior. Unilateral lesions of the MPOA/AH (medial preoptic area of the anterior hypothalamus) combined with unilateral lesions of the contralateral DLT result in defici...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00146-2
更新日期：1998-08-01 00:00:00
abstract：PURPOSE:Oxidative and inflammatory processes play a major role in stress-induced neural atrophy. There is a wide body of literature linking oxidative and inflammatory stress with reductions in neurotrophic factors, stress resilience, and cognitive function. Based on their antioxidant and anti-inflammatory capacity, we ...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2019.112650
更新日期：2019-11-01 00:00:00
abstract：:Resistance training (RT) has been shown to decrease fat mass (FM), and increase fat-free mass (FFM), which can be a useful for weight loss maintenance. OBJECTIVE:To examine the effects of a 1-year RT intervention on weight loss maintenance following a 6-month dietary weight loss intervention. DESIGN:Following a 6-mo...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2018.03.014
更新日期：2018-05-15 00:00:00
abstract：:Male hamsters were raised on short (SD) or long (LD) photoperiods from birth, and the expression of sexual behavior at 6, 7, 10, and 14 weeks was compared. Neither mounting, intromissions, ejaculations, nor ultrasonic vocalizations differed in the two groups until 14 weeks of age, when these behaviors were performed m...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90383-0
更新日期：1987-01-01 00:00:00
abstract：:Level of food restriction was manipulated in mice to assess its importance for the acquisition and expression of a conditioned odor discrimination. In training, animals were exposed to odors (either rose or lemon) presented on a piece of filter paper in a pot covered in bedding. For half of the conditioning trials, gr...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(00)00439-x
更新日期：2001-03-01 00:00:00
abstract：:For a given fish species, individuals are different in their ability to cope with stressors; each individual has its own set of physiological and behavioral responses to stress (stress-coping style). This individual diversity is of importance when considering the welfare of fish reared in aquaculture facilities. In th...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112576
更新日期：2019-09-01 00:00:00
abstract：:BDNF is strongly implicated in the development of depression. Recent evidence has indicated that tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) are related to the cleavage of pro-brain-derived neurotrophic factor (BDNF) into its mature form. Chronic unpredicted mild stress (CUMS) is w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.11.054
更新日期：2015-02-01 00:00:00
abstract：:Rats were exposed to daily sessions of either restraint plus cold, forced exercise, or grid shock for one month and then subjected to the ulcerogenic effects of either supine restraint plus cold, or activity-stress. Chronic stress generally protected against stress ulcer but the protection depended on the degree of si...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90493-2
更新日期：1986-01-01 00:00:00
abstract：:Ten Hooded Lister rats were divided from weaning into two groups of five. One group was fed exclusively on a liquid diet in the home cage (Complan-fed subjects), the other group was given normal laboratory chow (Chow-fed subjects). At approximately 60 days of age both groups were reduced to 80% of their ad lib body-we...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90062-3
更新日期：1984-01-01 00:00:00
abstract：:Female rats were used to examine the effects of chronic nicotine administration and withdrawal on food and water consumption and body weight. Rats with chronic nicotine pellet implants consumed significantly less food and water than controls for the first five days and then gradually returned to control levels of cons...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90370-2
更新日期：1987-01-01 00:00:00
abstract：:A simple device constructed from inexpensive components enables spike activity to be integrated and displayed in a convenient scale (spikes/sec) on a pen recorder. An input voltage threshold detection circuit is employed to eliminate any random baseline noise from being integrated. A pulse output is provided to drive ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(75)90151-1
更新日期：1975-01-01 00:00:00
abstract：:Four groups of female golden hamsters were exposed to short photoperiods (SP, LD 10:14) for 4, 14, 20, or 27 weeks and tested for physiological markers (uterine weight and estrous cycles) and behavioral (lordosis, approach and aggressive behaviors) measures while in contact with a stud male. After behavioral testing, ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90078-3
更新日期：1991-08-01 00:00:00
abstract：:This exploratory investigation examined the association between maximal aerobic power (VO2max) and blood pressure (BP) and heart rate (HR) reactivity to mental challenge. Adolescent male judo athletes (n = 20) performed a 2-min mental arithmetic. Heart rate was recorded before, during, and after the arithmetic, and BP...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90187-2
更新日期：1994-08-01 00:00:00
abstract：:There is some evidence suggesting that stress may induce diabetes mellitus; the effects of restraint stress however need to be investigated. The present study investigates the role of chronic restraint stress on carbohydrate metabolism in male rats. The animals of the stressed group (n=8) were exposed to different res...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.06.023
更新日期：2006-10-30 00:00:00
abstract：:The role of Pavlovian conditioning in humans with perennial allergic rhinitis was investigated using release of tryptase from sensitised mast cells as an indicator of allergic responsiveness. Challenge with house dust mite allergen (unconditioned stimulus) was paired with a drink of novel taste and appearance (conditi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90066-3
更新日期：1994-05-01 00:00:00
abstract：:Adequate energy intake is vital for the survival of humans and is regulated by complex homeostatic and hedonic mechanisms. Supported by functional MRI (fMRI) studies that consistently demonstrate differences in brain response as a function of weight status during exposure to appetizing food stimuli, it has been posite...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2014.04.025
更新日期：2014-09-01 00:00:00
abstract：:Many socially relevant odors are detected in rodent species by the vomeronasal organ and subsequently processed by the accessory olfactory system (AOS). We previously found that gonadectomized male and female rats treated in adulthood with testosterone propionate (TP) showed equivalent Fos responses in the AOS to odor...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00674-6
更新日期：2002-03-01 00:00:00
abstract：:Patients suffering from depression-associated cognitive impairments often recover incompletely after remission from the core symptoms of depression (lack of energy, depressed mood and anhedonia). This study aimed to set the basis for clinically relevant testing of cognitive impairments in a preclinical model of depres...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.11.010
更新日期：2018-02-01 00:00:00
abstract：:To compare food and water intakes, adult male Wistar rats were infused during 7 days with serotonin (5-HT, 2.5 nmol/24 h) or artificial cerebrospinal fluid (CSF) in the suprachiasmatic nucleus (SCN) in a three-way selection of macronutrient-rich diets. Nocturnal energy intake from the casein-rich diet was significantl...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(99)00142-0
更新日期：1999-12-01 00:00:00
abstract：:Sharpsnout seabream ability for macronutrient self-selection was studied using gelatine capsules containing pure macronutrients. In particular, the existence of non-oropharyngeal chemosensory pathways involved on protein (P), fat (F) and carbohydrate (CH) selection, as well as sharpsnout seabream response to dietary p...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.05.027
更新日期：2006-07-30 00:00:00
abstract：:Acquisition and reversal of a memory task dependent on hippocampal integrity were assessed in rats following chronic corticosterone treatment. Young adult male rats were injected daily with corticosterone (10 mg/kg, SC) for 8 weeks. Memory was assessed during the last week of treatment with an elevated platform maze. ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02172-8
更新日期：1996-06-01 00:00:00
abstract：:In each of eight cycles of repeated reward reduction, the performance of rats given brief access to 32% sucrose for 3 days, and then 4% sucrose for 2 days, was compared to rats that received 4% on all 5 days. Shifted rats consumed less than unshifted rats following each shift, with little evidence of diminution of neg...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(96)80043-6
更新日期：1996-08-01 00:00:00
abstract：:Single and population-mean cosinor analyses document a circadian rhythm in salivary cortisol of pigs (p < 0.001). The midline estimated statistic of rhythm, the MESOR (M), is 1.50 +/- 0.07 ng/ml. For the group of 14 pigs studied there was a predictable variation of 64% around this mean in salivary cortisol within a da...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(96)00107-2
更新日期：1996-09-01 00:00:00
abstract：:Fifteen adult female rats were subjected to one of the following surgical procedures: (1) bilateral neocortical ablation; (2) unilateral neocortical ablation; or (3) sham surgery. Following recovery, all rats were tested on a fixed-time 1-min food schedule for acquisition of schedule-induced polydipsia. Contrary to a ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90386-9
更新日期：1982-07-01 00:00:00
abstract：:Two experiments were performed to examine the acute effects of thirst-inducing stimuli upon the intake of tap water and ethanol solutions by golden hamsters, a species which avidly consumes ethanol solutions. In Experiment 1, three groups of adult male hamsters (n = 6/group) were maintained on Purina chow and tap wate...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90353-6
更新日期：1990-06-01 00:00:00
abstract：:The aim of this study was to investigate the mechanisms involved in the inhibitory action of progesterone on estrogen-induced facilitatory effects of estradiol benzoate on lordosis behavior in the male rat. Intact adult male rats were given 1) 25 micrograms estradiol benzoate (EB) and 100 micrograms progesterone (P) a...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90229-1
更新日期：1989-05-01 00:00:00
abstract：:Rats' voluntary ethanol intake varies with dispositional factors and energy status. The joint influences of these were of interest here. We previously reported that rats selectively bred for high voluntary saccharin intake (HiS) consume more ethanol and express more robust conditioning of preference for flavors paired...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.12.001
更新日期：2013-01-17 00:00:00
abstract：:One group of male rats was reared continuously in small, stable colonies of three animals each during a ten-week period beginning when they were 46 days old. A second group of animals was also reared in small groups of three animals each but membership within these colonies was randomly changed at weekly intervals. Th...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90373-1
更新日期：1984-10-01 00:00:00
