Serotonin infusion in the SCN reduces casein ingestion in rats.

Abstract:

:To compare food and water intakes, adult male Wistar rats were infused during 7 days with serotonin (5-HT, 2.5 nmol/24 h) or artificial cerebrospinal fluid (CSF) in the suprachiasmatic nucleus (SCN) in a three-way selection of macronutrient-rich diets. Nocturnal energy intake from the casein-rich diet was significantly lower during infusion of 5-HT than before infusion. Decrease in nocturnal casein consumption was significant in the middle dark phase. Within the infusion period, water intake was reduced by 5-HT infusion during the early, middle and late light phase. The present results reinforce the hypothesis of a serotonergic control of water intake and provide evidence for SCN 5-HT involvement in casein-specific dietary selection.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Thibault L,Mok E,Nagai K,Wong CY

doi

10.1016/s0031-9384(99)00142-0

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

37-45

issue

1-2

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(99)00142-0

journal_volume

68

pub_type

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