The effects of chronic corticosterone on memory performance in the platform maze task.

Abstract:

:Acquisition and reversal of a memory task dependent on hippocampal integrity were assessed in rats following chronic corticosterone treatment. Young adult male rats were injected daily with corticosterone (10 mg/kg, SC) for 8 weeks. Memory was assessed during the last week of treatment with an elevated platform maze. During acquisition trials, corticosterone-treated rats did not differ from vehicle-treated controls in either the location of first hole chosen nor in the latency to locate the escape hole. In the reversal trials, when the position of the escape hole was rotated 135 degrees, both groups successfully reversed their responses without persevering towards the previously rewarded escape hole location. These findings suggest that, despite the probability of corticosterone-induced changes in hippocampal physiology, chronic corticosterone treatment does not adversely affect performance in a memory task dependent on hippocampal integrity.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Bardgett ME,Newcomer JW,Taylor GT

doi

10.1016/0031-9384(95)02172-8

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

1111-5

issue

6

eissn

0031-9384

issn

1873-507X

pii

0031938495021728

journal_volume

59

pub_type

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