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Contribution of the amygdala to learning and performance of conditional fear.

Abstract：

:The amygdaloid complex appears to be an essential component in the neural systems mediating some forms of aversive Pavlovian conditioning. The relative contribution of this structure to acquisition and performance during fear conditioning was assessed by making temporary lesions in the amygdala prior to training or retention testing in a single-trial Pavlovian conditioning preparation. Microinjection of lidocaine HCl (5.0%, 1.0 microliters) into the amygdala prior to the presentation of a CS signalling footshock resulted in a significant attenuation of the performance of conditional fear, as indexed by the amount of time rats spent engaged in defensive freezing behavior during the retention session. However, similar treatment with lidocaine prior to the training session, during which the CS and UCS were paired, resulted in only a weak reduction in subsequent responding. Thus, while both acquisition- and performance-related processes take place within the amygdala, it appears that the latter are more sensitive to disruption using the present procedures. These results are discussed in terms of the general role played by this structure in aversive learning and motivational processes.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Helmstetter FJ

doi

10.1016/0031-9384(92)90320-2

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

1271-6

issue

6

eissn

0031-9384

issn

1873-507X

pii

0031-9384(92)90320-2

journal_volume

51

pub_type

杂志文章

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