A selective serotonin reuptake inhibitor reduces REM sleep in the homing pigeon.

Abstract:

:Avian and mammalian 'rapid eye movement' sleep (REM sleep) resemble each other in several aspects. However, the question of whether REM sleep has a shared evolutionary ancestry in birds and mammals has yet to be thoroughly explored. The brain regions and neurotransmitter systems involved in the generation of mammalian REM sleep are phylogenetically ancient, and are also found in extant birds and reptiles. Several pharmacological experiments in birds indicate that similar neural substrates are involved in the regulation of avian and mammalian sleep. However, because the drugs used in these studies generally resulted in non-specific sleep loss, the neurochemical regulation of avian REM sleep in particular remains uncertain. The selective serotonin reuptake inhibitor (SSRI) zimelidine is known to reduce REM sleep in mammals. If avian REM sleep is similarly regulated by serotonin, it would be expected that an acute dose of a SSRI should also reduce avian REM sleep. To investigate a putative role of serotonin in the regulation of avian REM sleep, changes in sleep electroencephalogram (EEG) and behavior were recorded in five pigeons (Columba livia) after the administration of an acute dose of zimelidine. Our results demonstrate that the effects of zimelidine on avian REM sleep are comparable to those observed in mammals, indicating that serotonin may serve a similar function in the control of avian and mammalian REM sleep.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Fuchs T,Siegel JJ,Burgdorf J,Bingman VP

doi

10.1016/j.physbeh.2005.12.003

subject

Has Abstract

pub_date

2006-03-30 00:00:00

pages

575-81

issue

3

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(05)00549-4

journal_volume

87

pub_type

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