Dietary modulation of oral amphetamine intake in rats.

Abstract:

:The interaction of sucrose availability and oral self-administration of amphetamine was examined in 23 male Sprague-Dawley rats. Fourteen rats were given a 0.075 mg/ml amphetamine sulfate solution as their sole source of fluid and 9 rats were given water. Feeding conditions were alternated between weeks with both granulated sucrose and chow available and weeks with only chow present. Rats drank significantly less of the amphetamine solution when consuming sucrose and chow than when eating chow alone. Sucrose intake had a slight effect on water intake. Rats drinking the amphetamine solution consumed significantly less food, gained significantly less weight, and were significantly less efficient at using calories for weight gain than rats drinking water. However, when given access to sucrose, rats drinking the amphetamine solution chose a significantly greater proportion of their daily caloric intake as sucrose (60%) than rats drinking water (42.5%). The present results demonstrate that 1) amphetamine intake alters nutrient choice and 2) that dietary variables can profoundly affect drug self-administration.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Kanarek RB,Marks-Kaufman R

doi

10.1016/0031-9384(88)90312-5

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

501-5

issue

4-5

eissn

0031-9384

issn

1873-507X

pii

0031-9384(88)90312-5

journal_volume

44

pub_type

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