Effect of naltrexone on food intake, hunger, and satiety in obese men.

Abstract:

:Increasing doses of naltrexone (25 to 200 mg) given over 4 consecutive days reduced intake of laboratory luncheon meals by 30% in 17 obese men. Meal size remained suppressed in the laboratory during the week following naltrexone administration. Water intake in the laboratory and body weight were not affected. Rates of ingestion and subjective ratings suggested that naltrexone reduced appetite rather than promoted early satiation. Nausea and other side effects occurred on 1 or 2 days during the naltrexone week in seven subjects whose food intake was reduced. Food intake was also reduced in seven of the remaining 10 subjects who reported no adverse reactions. These results suggest that a conditioned taste aversion or a conditioned anorexia may have developed in some subjects.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Spiegel TA,Stunkard AJ,Shrager EE,O'Brien CP,Morrison MF,Stellar E

doi

10.1016/0031-9384(87)90198-3

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

135-41

issue

2

eissn

0031-9384

issn

1873-507X

pii

0031-9384(87)90198-3

journal_volume

40

pub_type

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