Abstract:
:Spontaneous behavior patterns were assessed in eight different behavioral situations in two lines of mice, BR and BS, previously selected for their sensitivity to an anxiogenic benzodiazepine (BZ) receptor inverse agonist, Methyl beta-carboline-3-carboxylate (beta-CCM). BR is highly resistant, and BS, highly sensitive to beta-CCM-induced seizures. Tests used included an assessment of general locomotor activity, several situations classically used for measuring fear-motivated behaviors (open field, thigmotaxis, elevated plus-maze, light-dark discrimination, staircase), a test for measuring exploration (holeboard), and a test for measuring nociception (hot-plate). In the absence of beta-CCM, the results provide evidence of reduced motor activity and higher levels of anxiety in the BR line as compared to the BS line.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Suaudeau C,Rinaldi D,Lepicard E,Venault P,Crusio WE,Costentin J,Chapouthier Gdoi
10.1016/s0031-9384(00)00383-8subject
Has Abstractpub_date
2000-12-01 00:00:00pages
517-23issue
5eissn
0031-9384issn
1873-507Xpii
S0031-9384(00)00383-8journal_volume
71pub_type
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