Spike and wave complexes produced by four hallucinogenic compounds in the cat.

Abstract:

:The ability of four hallucinogenic compounds: ketamine, phencyclidine, quipazine and SKF-10,047 to produce spike and wave activity in the limbic system, was studied in cats with permanently implanted electrodes. Electronic frequency integrators were used to analyze the results and the percent of change in electrographic alterations was calculated. All the compounds studied, produced trains of 6/sec spike and waves complexes in the cingulum, rapid synchronous discharges in the amygdaloid complex, and slow wave synchronous activity and spiking in the septal areas. At low but hallucinatory concentrations of these drugs, the cortical EEG was not affected. Exploratory movements directed toward non-existent objects, classified as hallucinatory-like behavior, appeared simultaneous with these changes in the EEG recordings. It was concluded that there could exist a relationship between the appearance of 6/sec spike and wave complexes in the cingulum and the presence of hallucinations, produced by some synthetic drugs in the cat, this activity could be interpreted as the spreading of altered function of limbic and non-limbic nuclei related with this bundle which explain unspecificity of action.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Contreras CM,Guzman-Flores C,Mexicano G,Ervin FR,Palmour R

doi

10.1016/0031-9384(84)90240-3

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

981-4

issue

6

eissn

0031-9384

issn

1873-507X

pii

0031-9384(84)90240-3

journal_volume

33

pub_type

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