Hypophagia follows the initial hyperphagia produced by 2-deoxy-D-glucose in rats.

Abstract:

:The glucose analogue 2-deoxy-D-glucose (2DG) inhibits glucose metabolism and causes a rapid increase in food consumption in most species. This increase is most apparent during the first 6 postinjection hours, although it may persist as long as 10 hr. There are no published descriptions of alterations in food consumption subsequent to the hyperphagia. In the present study male and female rats were injected with 2DG (750 mg/kg IP), insulin (regular, 20 U/kg SC) or distilled water, and food intake was compared to baseline levels during the next 1, 6 and 24 hr. Results showed that food intake: (1) was not affected by injections of water: (2) was higher than normal during all 3 time periods following insulin injections: and (3) was higher than normal at 1 and 6 hr following 2DG, but significantly lower than normal by the end of 24 hr. The reasons underlying the development of hypophagia subsequent to the initial hyperphagia produced by 2DG are presently unknown.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Thompson CI,Zagon IS,McLaughlin PJ

doi

10.1016/0031-9384(79)90142-2

subject

Has Abstract

pub_date

1979-07-01 00:00:00

pages

187-90

issue

1

eissn

0031-9384

issn

1873-507X

pii

0031-9384(79)90142-2

journal_volume

23

pub_type

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