Abstract:
:EEG sleep recordings were performed in rats after administration of CCK-8. Mildly food-deprived rats were given IP CCK-8 (8 and 16 micrograms/kg body weight) and behavioural as well as EEG changes were examined. With 16 micrograms/kg of CCK-8, there was a significant increase of slow wave sleep in the 30 min of recording. Paradoxical sleep was unchanged or slightly decreased. The low dose of CCK-8 did not promote sleep. In addition both doses of CCK-8 induced EEG alterations including the presence of unusual acute spikes and slowing of EEG rhythm concomitant with awake immobility in rats. The computerized spectral analysis showed that CCK-8 slowed the EEG-wave frequency without modifying the total power energy in comparison with control wakefulness. In contrast, there was no effect in alcuronium-immobilized rats after 8 to 32 micrograms/kg IP of CCK-8. These observations do not support the idea that CCK-8, as a satiating factor like food, would promote sleep.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Depoortere H,De Saint-Hilaire Z,Nicolaïdis Sdoi
10.1016/0031-9384(90)90242-vsubject
Has Abstractpub_date
1990-12-01 00:00:00pages
873-7issue
6eissn
0031-9384issn
1873-507Xpii
0031-9384(90)90242-Vjournal_volume
48pub_type
杂志文章abstract::Polychlorinated biphenyls (PCBs) are pervasive environmental contaminants that can have damaging effects on physiologic, motoric and cognitive function. Results from studies on PCBs and behavior have shown that exposure can alter learning and memory processes and that these shifts in cognitive abilities can be related...
journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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更新日期:1983-01-01 00:00:00
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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