Abstract:
:Male and female spontaneously hypertensive (SHR), Wistar-Kyoto (WKY), and Sprague-Dawley (SD) rats were assessed at one of two ages (postnatal day 74 or 346) for open field locomotor activity and anxiety-related behavior in the elevated plus maze (EPM). In general, the SHR displayed the least anxiety-related behavior, an effect that was magnified with age. At 11 months of age, the SHR more frequently entered and remained longer in the open arms than either the SD or the WKY strains. EPM behavior of the WKY strain was much less affected by age than that of the SD strain which displayed increased anxiety-related behavior with age. At the younger age, the typical sex effects were apparent; specifically, females exhibited a shorter duration in the closed arms. While the SHR were the most active strain in the EPM at both ages, they were more active in the open field only at the older age. In general, age-related changes in open field activity mirrored those of the EPM. These results provide a more comprehensive illustration of aging-related behavioral changes in male and female SHR, WKY and SD rats.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Ferguson SA,Gray EPdoi
10.1016/j.physbeh.2005.06.009subject
Has Abstractpub_date
2005-08-07 00:00:00pages
621-8issue
5eissn
0031-9384issn
1873-507Xpii
S0031-9384(05)00224-6journal_volume
85pub_type
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