Effect of intracerebroventricular administration of vasopressin on stress-induced hyperthermia in rats.

Abstract:

:Vasopressin has been reported to be an endogenous antipyretic peptide. The present study assessed whether this peptide has similar effects on stress-induced hyperthermia. Infusion of 3 ng of vasopressin into the lateral ventricle prior to a 40-min restraint stress reduced significantly the hyperthermic response of rats to this stress, compared to saline-injected controls. Half of the vasopressin-injected animals showed an immediate hypothermic response, with a significant reduction in body temperature of 0.34 degree C or more within 10 min; however, the effect of vasopressin on stress-induced hyperthermia remained significant after exclusion of these animals from the analysis. Administration of a V1 receptor antagonist prior to the stress did not affect the hyperthermic response, which may suggest that the hyperthermic response had reached maximal (ceiling) levels. Administration of vasopressin, or of the V1 receptor antagonist immediately after the stress, did not affect defervescence, suggesting that vasopressinergic systems are not implicated in the defervescence process. Thus, the results show that ICV administration of vasopressin reduces stress-induced hyperthermia. The mechanisms underlying the effects remain to be elucidated.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Terlouw EM,Kent S,Cremona S,Dantzer R

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

417-24

issue

2

eissn

0031-9384

issn

1873-507X

pii

0031938496872180

journal_volume

60

pub_type

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