Abstract:
:It has been demonstrated that the ventromedial hypothalamus (VMH) of alloxan-induced diabetic mice is protected from subsequent gold thioglucose (GTG)-induced lesions. Another compound, 3,3'-methyliminobis-(N-methylpropylamine) (MIMPA), a triamine structurally unrelated to GTG, has been shown to cause similar VMH lesions in mice. We chose to investigate the effect of alloxan-induced diabetes on VMH lesion formation in MIMPA-treated mice. In this study CF-1 female mice were made diabetic by a simple intravenous (IV) injection of alloxan and subsequently treated with MIMPA by subcutaneous injection (SC). Contrary to studies which showed that GTG-induced VMH lesions are insulin dependent, an insulin deficiency did not inhibit MIMPA-induced lesions in the VMH of mice. Our data suggests, albeit GTG is suspected to induce VMH necrosis by attaching to glucoreceptors and insulin-sensitive neurons, MIMPA works by a different and as yet unknown mechanism. We conclude that MIMPA-induced lesions in the VMH of mice are not insulin dependent.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Brown DF,McGuirk JP,Larsen SP,Minter SDdoi
10.1016/0031-9384(91)90227-fsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
41-6issue
1eissn
0031-9384issn
1873-507Xpii
0031-9384(91)90227-Fjournal_volume
49pub_type
杂志文章abstract::Individual variation in the way animals cope with stressors has been documented in a number of animal groups. In general, two distinct sets of behavioural and physiological responses to stress have been described: the proactive and the reactive coping styles. Some characteristics of stress coping style seem to be coup...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.02.025
更新日期:2011-06-01 00:00:00
abstract::Explicit cues associated with food consumption when hunger prevails will enhance eating when they are subsequently presented under conditions of satiety. Here we examined whether contextual conditioned stimuli (CSs) paired with consumption of food pellets while rats were food-deprived would enhance consumption of this...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.09.031
更新日期:2007-02-28 00:00:00
abstract::Umami tasting substances, MSG (monosodium glutamate), HG (glutamic acid), LGDE (1-glutamic acid diethyl ester), DLHCA (dl-homocysteic acid), DLAAA (dl-aminoadipic acid) and 5'GMP, were tested on the hamster and the human. Ten mM MSG was routinely used in the hamster as it elicited strong chorda tympani responses. Simi...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90202-y
更新日期:1991-05-01 00:00:00
abstract::This review article discusses the well-established role of the dorsomedial hypothalamic nucleus (DMN) in feeding, drinking and body weight (BW) regulation. DMN lesions (L) in both weanling and mature rats of both sexes produce hypophagia, hypodipsia and reduced ponderal and linear growth in the presence of normal body...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/s0031-9384(02)00756-4
更新日期:2002-07-01 00:00:00
abstract:PURPOSE:Oxidative and inflammatory processes play a major role in stress-induced neural atrophy. There is a wide body of literature linking oxidative and inflammatory stress with reductions in neurotrophic factors, stress resilience, and cognitive function. Based on their antioxidant and anti-inflammatory capacity, we ...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2019.112650
更新日期:2019-11-01 00:00:00
abstract::Female mate choice is often investigated in terms of reproductive success in order to understand how male characteristics contribute to sexual attractiveness. Previous studies have found that females rats prefer mating with their first encounter rather than males visited subsequently, suggesting that the rewarding val...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2017.10.031
更新日期:2018-02-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.08.009
更新日期:2012-01-18 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(96)00134-5
更新日期:1996-10-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00170-4
更新日期:1997-09-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90261-1
更新日期:1986-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(85)90099-x
更新日期:1985-02-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)00050-s
更新日期:1995-08-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90209-5
更新日期:1987-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(75)90158-4
更新日期:1975-02-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(98)00232-7
更新日期:1999-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(88)90242-9
更新日期:1988-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113266
更新日期:2021-03-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2016.04.029
更新日期:2016-10-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2016.08.013
更新日期:2016-10-15 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.03.014
更新日期:2015-05-15 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(88)90145-x
更新日期:1988-01-01 00:00:00
abstract::To examine the functional relationships between the dorsal raphe nucleus and the septum in the inhibitory regulation of feminine sexual behavior in male rats, castrated male rats received destruction of the dorsal raphe nucleus (DRL), interruption of the septal outputs (ARD), or both DRL and ARD (DRL+ARD). All animals...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90278-x
更新日期:1994-07-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2005.07.006
更新日期:2005-09-15 00:00:00
abstract::Many promising findings from pre-clinical research have failed to translate to the clinic due to their inability to incorporate human disease co-morbidity. A variety of rodent diets and feeding durations are currently used in models of human metabolic syndrome, obesity and diabetes. One model, the Cafeteria (CAF) diet...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2016.09.029
更新日期:2016-12-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.03.031
更新日期:2007-08-15 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.05.011
更新日期:2004-09-30 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(77)90174-3
更新日期:1977-07-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.06.014
更新日期:2011-10-24 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)00211-m
更新日期:1995-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90306-8
更新日期:1984-04-01 00:00:00