Abstract:
:To investigate brain substrates of spatial memory, neuronal expression of c-Fos protein was studied. Two groups of rats were trained in two spatial memory tasks in the Morris water maze, where the rats have to apply a reference memory rule or a working memory rule. In addition to the experimental groups, two control groups were used to study c-fos activation not specific to the memory processes studied. After immunohistochemical procedures, the number of c-Fos positive neuronal nuclei was quantified in the mammillary body (MB) region (medial mammillary nucleus [MMn] and supramammillary nucleus [SuM]). The results have shown that some MMn neurons expressed c-Fos nuclear immunoreactivity related to spatial working memory but not to spatial reference memory. The increased number of c-Fos immunoreactive neuronal nuclei in the SuM was related to spatial training but not to either working or reference memory demands of the tasks.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Santín LJ,Aguirre JA,Rubio S,Begega A,Miranda R,Arias JLdoi
10.1016/s0031-9384(03)00060-xsubject
Has Abstractpub_date
2003-04-01 00:00:00pages
733-9issue
4-5eissn
0031-9384issn
1873-507Xpii
S003193840300060Xjournal_volume
78pub_type
杂志文章abstract::Long-term exposure to stress and its physiological mediators, in particular cortisol, may lead to impaired telomere maintenance. In this study, we examine if greater cortisol responses to an acute stressor and/or dysregulated patterns of daily cortisol secretion are associated with shorter telomere length. Twenty-thre...
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