2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus.

Abstract:

:The role of the endocannabinoid system in vomiting has been previously studied using several animal species. These investigations have clearly demonstrated an anti-emetic role for the eCB, anandamide, in these animal models; however, research concerning the role of 2-arhachidonoylglycerol (2AG) has been less clear. The aim of the present study was to assess the effects of exogenous 2AG administration in the house musk shrew, Suncus murinus. In Experiment 1, shrews were injected with vehicle or 2AG (1, 2, 5, 10 mg/kg) 15 min prior to behavioral testing in which the frequency of vomiting episodes was observed. In Experiment 2, shrews were pre-treated with 2AG (2, 5 mg/kg) prior to being administered the emetic drug, lithium chloride (LiCl). It was found that 2AG alone did not induce emesis, but interfered with vomiting in response to LiCl administration. The anti-emetic effects of 2AG in Suncus murinus do not appear to be mediated by CB1 receptors, as concomitant pretreatment with the CB1 receptor antagonist, SR141716, did not reverse the suppressive effects of 2AG. These results confirm that manipulations that increase levels of 2AG exert anti-emetic effects in the house musk shrew.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Sticht MA,Rock EM,Parker LA

doi

10.1016/j.physbeh.2013.08.015

subject

Has Abstract

pub_date

2013-08-15 00:00:00

pages

228-32

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(13)00263-1

journal_volume

120

pub_type

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