Time-restricted feeding attenuates gluconeogenic activity through inhibition of PGC-1α expression and activity.


BACKGROUND:Time-restricted feeding (TRF), a key component of intermittent fasting regimens, has gained considerable attention in recent years due to reversing obesity and insulin resistance. To the best of our knowledge, here, we reported for the first time the underlying mechanistic therapeutic efficacy of TRF against hepatic gluconeogenic activity in obese mice. METHODS:The obese mice were subjected to either ad lib or TRF of a high fat diet for 8 h per day for 4 weeks. Western blotting, qRT-PCR, and plasma biochemical analyses were applied. RESULTS:The present findings showed that TRF regimen reduced food intake, and reversed high fat diet-induced glucose intolerance, hyperglycemia and insulin resistance in mice of high fat diet-induced obesity. Mechanistically, we confirmed that TRF regimen protected against hyperglycemia and ameliorated hepatic gluconeogenic activity through inhibition of p38 MAPK/SIRT1/PGC-1α signal pathway. CONCLUSION:Our findings suggest that TRF regimen might be a potential novel nonpharmacological strategy against obesity/diabetes-induced hyperglycemia and insulin resistance.


Physiol Behav


Physiology & behavior


She Y,Sun J,Hou P,Fang P,Zhang Z




Has Abstract


2021-03-15 00:00:00












  • Effect of handling on neurotransmitter profile in pig brain according to fear related behaviour.

    abstract::Chemical neurotransmitters (NT) are principal actors in all neuronal networks of animals. The central nervous system plays an important role in stress susceptibility and organizes the response to a stressful situation through the interaction of the dopaminergic and the serotonergic pathways, leading to the activation ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Arroyo L,Carreras R,Valent D,Peña R,Mainau E,Velarde A,Sabrià J,Bassols A

    更新日期:2016-12-01 00:00:00

  • State, but not trait gratitude is associated with cardiovascular responses to acute psychological stress.

    abstract::Recent research suggests that gratitude is associated with better cardiovascular health. Here, we investigated whether trait and/or state gratitude was associated with cardiovascular responses to acute stress. Eighty-six young adults completed measures of gratitude and had their cardiovascular responses monitored thro...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Gallagher S,Solano AC,Liporace MF

    更新日期:2020-07-01 00:00:00

  • Effects of ability- and chance-determined competition outcome on testosterone.

    abstract::Winning competitions has been shown to lead to higher testosterone (T) relative to losing in men and males of other species. In Experiment 1, 38 women and 37 men provided a saliva sample, completed a novel computer-based vocabulary competition task at which they won or lost based on their own ability, provided feedbac...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: van Anders SM,Watson NV

    更新日期:2007-03-16 00:00:00

  • Social stability attenuates the stress in the modified multiple platform method for paradoxical sleep deprivation in the rat.

    abstract::The instrumental methods to induce paradoxical sleep (PS) deprivation are stressful. The modified multiple platform method (MMPM), in which animals are placed with new cohorts inside the water tanks, results in augmented ACTH and corticosterone (CORT) responses. We hypothesised that this increased response could be at...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Suchecki D,Tufik S

    更新日期:2000-01-01 00:00:00

  • Daytime cold exposure and salt intake based on nocturnal urinary sodium excretion: A cross-sectional analysis of the HEIJO-KYO study.

    abstract::Increased cardiovascular incidence in winter is partly explained by higher blood pressure due to cold exposure. Although higher salt intake induced by cold exposure has been reported in mice, the association remains unclear in humans. To investigate the association between salt intake and cold exposure in winter, a cr...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Saeki K,Obayashi K,Tone N,Kurumatani N

    更新日期:2015-12-01 00:00:00

  • Chronic stress in dogs subjected to social and spatial restriction. II. Hormonal and immunological responses.

    abstract::Two groups of beagles, accustomed to spacious group housing, were subjected to social and spatial restriction and studied for manifestations of chronic stress with a time interval of 7 weeks between the groups. The change from outside group housing (the control period) to individual housing in small indoor kennels res...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Beerda B,Schilder MB,Bernadina W,van Hooff JA,de Vries HW,Mol JA

    更新日期:1999-04-01 00:00:00

  • Impairment of thermoregulatory cooling behavior by single cortical spreading depression in the rat.

    abstract::Effects of single waves of unilateral cortical spreading depression (CSD) on skin-cooling operant behavior were studied in the rat with and without unilateral lesion in the preoptic and anterior hypothalamus (PO/AH). The skin-cooling behavior was severely suppressed for 6 min, with a resulting rise in rectal temperatu...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Shibata M,Hori T,Kiyohara T,Nakashima T,Osaka T

    更新日期:1983-04-01 00:00:00

  • Lymphocytes and monocytes egress peripheral blood within minutes after cessation of steady state exercise: A detailed temporal analysis of leukocyte extravasation.

    abstract::Acute exercise evokes an almost instantaneous lymphocytosis, followed by sustained lymphopenia that occurs within just 30-60 min after exercise cessation. The aim of this study was to characterize the immediate (order of minutes) post-exercise kinetics of lymphocyte and monocyte egress, and to determine whether this e...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Rooney BV,Bigley AB,LaVoy EC,Laughlin M,Pedlar C,Simpson RJ

    更新日期:2018-10-01 00:00:00

  • Consolidation and expression of a shock-induced odor preference in rat pups is facilitated by opioids.

    abstract::To support nipple attachment and huddling, rat pups must learn to approach and prefer maternal odor. Similar to other altricial species, rat pups have a sensitive period for learning this odor preference, which ends around postnatal day (PN) 10 and coincides with the emergence of walking. One characteristic of this se...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Roth TL,Sullivan RM

    更新日期:2003-01-01 00:00:00

  • Rough-and-tumble play behavior in Fischer-344 and buffalo rats: effects of social isolation.

    abstract::Play behavior was assessed in two inbred strains of rats. Rats of the Fischer-344 strain (F344) were found to be less playful than Buffalo rats after social isolation, as evident from fewer pins and fewer playful attacks to the nape. When tested in same-strain pairings, overall defense of the nape did not differ betwe...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Siviy SM,Baliko CN,Bowers KS

    更新日期:1997-04-01 00:00:00

  • Conditioned avoidance behavior in pretrained rats intermittently treated with addictive drugs.

    abstract::Rats pretrained in a conditioned avoidance (CAR) paradigm were put on eight potentially addictive drugs in drinking water at two dose levels each. Fluid intake and body weight, monitored during the drugged (addiction) and nondrugged (withdrawal) states, showed drug/dose-dependent fluctuations in most groups. Extinctio...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Banerjee U

    更新日期:1975-09-01 00:00:00

  • Effects of drinks sweetened with sucrose or aspartame on hunger, thirst and food intake in men.

    abstract::Forty-two nondieting adult males were given 8 or 16 oz of lemonade, sweetened to equal intensity with either aspartame or sucrose, or the same volumes of water, or no drink. Subjects were separated into three groups receiving the drinks at different times: with a self-selection lunch, or 30, or 60 min before lunch. Fo...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Rolls BJ,Kim S,Fedoroff IC

    更新日期:1990-07-01 00:00:00

  • Thermal comfort following immersion.

    abstract::Unlike thermal comfort in air, little research has been undertaken exploring thermal comfort around water sports. We investigated the impact of swimming and cooling in air after swimming on thermal comfort. After 10 min of swimming-and-resting cycles in 28°C water, volunteers wearing two types of garments or in swim b...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Guéritée J,Redortier B,House JR,Tipton MJ

    更新日期:2015-02-01 00:00:00

  • Behavioral models of binge-type eating.

    abstract:PURPOSE:To describe and evaluate behavioral models of binge-type eating. DATA IDENTIFICATION:Studies were identified using Medline and hand searches of bibliographies of identified articles. STUDY SELECTION:Isomorphic studies were selected that were judged to have some measure of construct validity. DATA EXTRACTION:...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审


    authors: Corwin RL,Buda-Levin A

    更新日期:2004-08-01 00:00:00

  • Adrenal modulation of parental behavior in neonatally gonadectomized C57BL/6J male mice.

    abstract::C57BL/6J male mice ordinarily kill neonatal mouse pups even if they are rendered androgen deficient by neonatal castration. Experiment 1 showed that adrenalectomy during adult life significantly decreased the tendency of neonatally gonadectomized males to kill newborns. Experiment 2 demonstrated that testosterone expo...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Kinsley C,Svare B

    更新日期:1987-01-01 00:00:00

  • Neuroticism is associated with reduced oxygenation levels in the lateral prefrontal cortex following exposure to unpleasant images.

    abstract::The aim of this study was to explore the prefrontal cortex response to emotional salient stimuli in subjects with high scores in Neuroticism (and low in Sensation Seeking) or high scores in Sensation Seeking (and low in Neuroticism) personality traits, -called now Neuroticism and Sensation Seeking groups-. For this pu...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Balada F,Lucas I,Blanch Á,Blanco E,Aluja A

    更新日期:2019-02-01 00:00:00

  • Elevated plus-maze behavior in adult offspring of selectively bred rats.

    abstract::Animals sampled from the third generation (S3) of selective breeding of N:NIH strain rats based on ultrasonic vocalization (USV) rates in infancy (High, Low, and Random lines) were tested as adults on the elevated plus maze, a well-validated test of anxiety. Results showed that the Low line spent a greater percent of ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Dichter GS,Brunelli SA,Hofer MA

    更新日期:1996-07-01 00:00:00

  • Influence of conditioned stimulus context on hyperglycemic conditioned responses.

    abstract::Glycemic conditioning was investigated in four experiments in which insulin was administered to animals in particular stimulus contexts. Both hyperglycemic and hypoglycemic conditioned responses were obtained, with the directionality of the CR dependent upon which environmental complex was used as the CS. These bidire...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Flaherty CF,Becker HC

    更新日期:1984-10-01 00:00:00

  • Liver of ovariectomized rats is resistant to resorption of lipids.

    abstract::Ovarian hormones have been shown to regulate liver lipid accumulation in rats. The present study was designed to evaluate liver lipid resorption in ovariectomized (Ovx) rats. Ovx and sham-operated (Sham) rats were submitted to a high-fat (HF; 43% kcal fat as energy) diet for 5 weeks and then either maintained on this ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Barsalani R,Pighon A,Rabasa-Lhoret R,Yasari S,Lavoie JM

    更新日期:2008-09-03 00:00:00

  • Rare genetic forms of obesity: From gene to therapy.

    abstract::Monogenic non-syndromic obesity is characterized by severe early-onset obesity with abnormal eating behaviour and endocrine disorders. Genes contributing to these rare forms of obesity are mainly located in the leptin/melanocortin pathway, with typically an autosomal additive inheritance of obesity. The normal functio...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Clément K,Mosbah H,Poitou C

    更新日期:2020-12-01 00:00:00

  • Effects of single and repeated restraint on the social behavior of male rats.

    abstract::The effects of a mild, nonpainful stressor (restraint, RT) on the social behavior of male rats were explored. Twenty-four hours after single or repeated RT, experimental subjects were confronted in a neutral cage with unfamiliar and naive opponents of the same sex and strain, matched for age and body weight. Introduct...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Albonetti ME,Farabollini F

    更新日期:1993-05-01 00:00:00

  • Sheep and goat saliva proteome analysis: a useful tool for ingestive behavior research?

    abstract::Sheep and goats differ in diet selection, which may reflect different abilities to deal with the ingestion of plant secondary metabolites. Although saliva provides a basis for immediate oral information via sensory cues and also a mechanism for detoxification, our understanding of the role of saliva in the pre-gastric...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Lamy E,da Costa G,Santos R,Capela E Silva F,Potes J,Pereira A,Coelho AV,Sales Baptista E

    更新日期:2009-10-19 00:00:00

  • Sleep profile during fasting in PPAR-alpha knockout mice.

    abstract::Peroxisome proliferator-activated receptor alpha (PPARα) is a transcription factor that belongs to the nuclear receptor family and plays an important role in regulating gene expression associated with lipid metabolism. PPARα promotes hepatic fatty acid oxidation and ketogenesis in response to fasting. Because energy m...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Kondo Y,Chikahisa S,Shiuchi T,Shimizu N,Tanioka D,Uguisu H,Séi H

    更新日期:2020-02-01 00:00:00

  • Distinct substrates influence the acquisition of self-stimulation of the hippocampus and the prefrontal cortex.

    abstract::Self-stimulation (SS) of both the medial prefrontal cortex (MPFC) and the dorsolateral hippocampus (HPC) is known to develop slowly, over a period of days. In both cases, the acquisition of bar-pressing can be markedly hastened by delivery of noncontingent electrical stimulation for several days prior to SS training. ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Robertson A,Laferrière A,Milner PM

    更新日期:1986-01-01 00:00:00

  • Morphine and dextrorphan lose antinociceptive activity but exhibit an antispastic action in chronic spinal rats.

    abstract::Within 3-4 weeks after spinal transection, morphine-induced antinociception, assessed with the tail flick reflex in rats, is profoundly reduced. The cause of this decrement is unknown. The present studies were conducted to determine whether this phenomenon reflects a general loss in opiate activity or a selective decl...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Advokat C,Mosser H,Hutchinson K

    更新日期:1997-10-01 00:00:00

  • The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: lessons learned from lesioning studies.

    abstract::This review article discusses the well-established role of the dorsomedial hypothalamic nucleus (DMN) in feeding, drinking and body weight (BW) regulation. DMN lesions (L) in both weanling and mature rats of both sexes produce hypophagia, hypodipsia and reduced ponderal and linear growth in the presence of normal body...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审


    authors: Bellinger LL,Bernardis LL

    更新日期:2002-07-01 00:00:00

  • Baseline transition sleep and associated sleep episodes are related to the learning ability of rats.

    abstract::The EEGs of 18 adult male Wistar rats were recorded during a baseline session lasting 7 h (day 1). The following day, rats were trained for a 2-way active avoidance task in an automated shuttle-box. A retention test was scheduled on the third day. On the basis of the number of avoidances scored during the training and...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Vescia S,Mandile P,Montagnese P,Romano F,Cataldo G,Cotugno M,Giuditta A

    更新日期:1996-12-01 00:00:00

  • The influence of a glucose drink on a demanding working memory task.

    abstract::A group of young adult females, who had or had not eaten breakfast, drank either a glucose drink or a placebo. Fasting was associated with poorer performance on the Brown-Petersen task, a test of memory. A glucose drink improved the memory of those who had fasted, although it did not influence those who had eaten brea...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Martin PY,Benton D

    更新日期:1999-08-01 00:00:00

  • Maternal resistance exercise promotes changes in neuroplastic and epigenetic marks of offspring's hippocampus during adult life.

    abstract::Studies indicate that gestational exercise practice positively impacts the offspring's cognition. Nevertheless, the influence of maternal resistance exercise, different periods of exercise practice, and the inter- and transgenerational effects involved in these responses are not known. This study sought to report the ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Meireles ALF,Segabinazi E,Spindler C,Gasperini NF,Souza Dos Santos A,Pochmann D,Elsner VR,Marcuzzo S

    更新日期:2021-03-01 00:00:00

  • Schedule-induced polydipsia experience decreases plasma corticosterone levels but increases plasma prolactin levels.

    abstract::To determine the neuroendocrine pattern of response to excessive drinking induced by exposure of rats to an intermittent distribution of food (schedule-induced polydipsia, SIP), the present experiment investigated changes in plasma corticosterone, prolactin and catecholamines in chronically catheterized rats that had ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章


    authors: Dantzer R,Terlouw C,Mormède P,Le Moal M

    更新日期:1988-01-01 00:00:00