Time-restricted feeding attenuates gluconeogenic activity through inhibition of PGC-1α expression and activity.

Abstract:

BACKGROUND:Time-restricted feeding (TRF), a key component of intermittent fasting regimens, has gained considerable attention in recent years due to reversing obesity and insulin resistance. To the best of our knowledge, here, we reported for the first time the underlying mechanistic therapeutic efficacy of TRF against hepatic gluconeogenic activity in obese mice. METHODS:The obese mice were subjected to either ad lib or TRF of a high fat diet for 8 h per day for 4 weeks. Western blotting, qRT-PCR, and plasma biochemical analyses were applied. RESULTS:The present findings showed that TRF regimen reduced food intake, and reversed high fat diet-induced glucose intolerance, hyperglycemia and insulin resistance in mice of high fat diet-induced obesity. Mechanistically, we confirmed that TRF regimen protected against hyperglycemia and ameliorated hepatic gluconeogenic activity through inhibition of p38 MAPK/SIRT1/PGC-1α signal pathway. CONCLUSION:Our findings suggest that TRF regimen might be a potential novel nonpharmacological strategy against obesity/diabetes-induced hyperglycemia and insulin resistance.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

She Y,Sun J,Hou P,Fang P,Zhang Z

doi

10.1016/j.physbeh.2021.113313

subject

Has Abstract

pub_date

2021-03-15 00:00:00

pages

113313

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(21)00005-6

journal_volume

231

pub_type

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